Metabolic syndrome and non-alcoholic fatty liver disease
Metabolic syndrome and non-alcoholic fatty liver disease
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DOI：
10.1016/s1665-2681(19)31822-8
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发表时间：
2009-01-01
影响因子：
3.8
通讯作者：
Aguilar-Salinas, Carlos Alberto
中科院分区：
文献类型：
--
作者：
Almeda-Valdes, Paloma;Cuevas-Ramos, Daniel;Aguilar-Salinas, Carlos Alberto
非酒精性脂肪性肝病（NAFLD）的发展与代谢综合征密切相关，这反映在以下事实中：约90%的NAFLD患者具有一种以上的代谢综合征特征，约33%的患者具有三种或三种以上的标准。本文就该病的病理生理学、流行病学和治疗方面的研究进展作一综述。脂毒性在这两种疾病的病理生理学中起着主要作用。由于脂肪酸的摄取、合成、输出和氧化之间的不平衡，它导致甘油三酯在肝脏中积累。这两种情况在墨西哥都很常见。使用成人治疗小组诊断标准，1994年代谢综合征的患病率为26.6%。虽然NAFLD的患病率尚不清楚，但可以从肥胖的患病率（30%）来估计。由于在超过三分之二的肥胖受试者中发现了NAFLD，因此这种情况可能存在于20%的成年人群中。这两种情况的治疗应基于整体方法，包括采用健康的生活方式，减肥和药物治疗。总之，NAFLD是代谢综合征的肝脏表达。对这些疾病的研究和治疗不能被视为单独的问题。
The development of nonalcoholic fatty liver disease (NAFLD) is strongly associated with the metabolic syndrome as reflected by the fact that approximately 90% of the patients with NAFLD have more than one feature of metabolic syndrome and about 33% have three or more criteria. The physiopathology, epidemiology and therapeutic considerations of the disease are reviewed here. Lipotoxicity plays a predominant role in the pathophysiology of both entities. It leads to accumulation of triglycerides in the liver as a result of an imbalance among the uptake, synthesis, export, and oxidation of fatty acids. Both conditions are very common in Mexico. Using the Adult Treatment Panel diagnostic criteria, the 1994 prevalence of the metabolic syndrome was 26.6%. Although the prevalence of NAFLD is not known, but it can be estimated from the prevalence of obesity (30%). Since NAFLD is found in over two thirds of the obese subjects, this condition may exist in 20% of the adult population. The treatment of both conditions should be based in an integral approach, including the adoption of a healthy lifestyle, weight loss and may be pharmacotherapy. In summary, NAFLD is the hepatic expression of the metabolic syndrome. The study and treatment of these disorders could not be viewed as separate issues.