Role of extrahepatic UDP-glucuronosyltransferase 1A1: Advances in understanding breast milk-induced neonatal hyperbilirubinemia.
Role of extrahepatic UDP-glucuronosyltransferase 1A1: Advances in understanding breast milk-induced neonatal hyperbilirubinemia.
复制标题
肝外UDP-葡萄糖基转移酶1A1的作用：理解母乳诱导的新生儿高脂蛋白血症的进步。
DOI：
10.1016/j.taap.2015.08.018
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发表时间：
2015-11-15
影响因子：
3.8
通讯作者：
Tukey RH
中科院分区：
文献类型：
--
作者：
Fujiwara R;Maruo Y;Chen S;Tukey RH
新生儿通常会出现生理性高胆红素血症（也称为黄疸）。随着在母乳喂养的婴儿中观察到胆红素水平升高，母乳喂养已被认为是新生儿高胆红素血症发展的一个促进因素。胆红素经过udp -葡萄糖醛酸转移酶（UGT） 1A1的选择性代谢，成为水溶性葡萄糖醛酸盐。虽然一些因素，如胎龄、脱水和体重减轻、肠肝循环增加与母乳性黄疸（BMJ）有关，但UGT1A1表达不足是BMJ的一个已知原因。目前认为，非共轭胆红素主要在肝脏代谢。然而，最近的研究结果支持肝外组织，如小肠和皮肤，在新生儿时期有助于胆红素糖醛酸化的概念。我们将回顾最近在了解影响BMJ的生物学和分子事件方面取得的进展，特别是关于肝外UGT1A1表达的作用。
Newborns commonly develop physiological hyperbilirubinemia (also known as jaundice). With increased bilirubin levels being observed in breast-fed infants, breast-feeding has been recognized as a contributing factor for the development of neonatal hyperbilirubinemia. Bilirubin undergoes selective metabolism by UDP-glucuronosyltransferase (UGT) 1A1 and becomes a water soluble glucuronide. Although several factors such as gestational age, dehydration and weight loss, and increased enterohepatic circulation have been associated with breast milk-induced jaundice (BMJ), deficiency in UGT1A1 expression is a known cause of BMJ. It is currently believed that unconjugated bilirubin is metabolized mainly in the liver. However, recent findings support the concept that extrahepatic tissues, such as small intestine and skin, contribute to bilirubin glucuronidation during the neonatal period. We will review the recent advances made towards understanding biological and molecular events impacting BMJ, especially regarding the role of extrahepatic UGT1A1 expression.