Secondary Metabolites from the Endophytic Fungus Xylaria cubensis
Secondary Metabolites from the Endophytic Fungus Xylaria cubensis
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DOI：
10.1002/hlca.201400091
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发表时间：
2014-12-01
影响因子：
1.8
通讯作者：
Chen, Ih-Sheng
中科院分区：
文献类型：
--
作者：
Fan, Nai-Wen;Chang, Hsun-Shuo;Chen, Ih-Sheng
七种新代谢物，包括三种倍半萜类化合物，10-羟基罗汉柏烯 (1)、阿科三醇 (2) 和木糖三醇 (3)，一种二萜类化合物，立方体三醇 (4)，一种脂肪族衍生物，阿科烯酸 (5)，一种生物碱，阿科二离子 (6)，和一种异香豆素，阿科利色林 (7)，以及七种已知化合物，图8-14是从源自樟科木姜子(Litsea akoensis Hayata)叶子的内生真菌Xylariacubensis的发酵液的AcOEt可溶级分中分离出来的。它们的结构通过光谱分析（包括一维和二维核磁共振实验）以及 HR-ESI-MS 质谱法得以阐明。在分离株中，(-)-(R)-7-羟蜜肽显示出IL-6抑制活性，IC50值为9.41μm。
Seven new metabolites, including three sesquiterpenoids, 10-hydroxythujopsene (1), akotriol (2), and xylaritriol (3), one diterpenoid, cubentriol (4), one aliphatic derivative, akoenic acid (5), one alkaloid, akodionine (6), and one isocoumarin, akolitserin (7), together with seven known compounds, 8 - 14, were isolated from the AcOEt-soluble fraction of the fermentation broth of the endophytic fungus Xylaria cubensis, derived from the leaves of Litsea akoensis Hayata (Lauraceae). Their structures were elucidated by spectroscopic analyses, including 1D- and 2D-NMR experiments, and by HR-ESI-MS mass spectrometry. Among the isolates, (-)-(R)-7-hydroxymellein showed IL-6 inhibitory activity with an IC50 value of 9.41 mu m.