Fc‐rosetting and nonrosetting T cells are killer cells
Fc‐rosetting and nonrosetting T cells are killer cells
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Fc 玫瑰花形成和非玫瑰花形成 T 细胞是杀伤细胞
DOI：
10.1002/eji.1830060214
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发表时间：
1976
影响因子：
5.4
通讯作者：
H. von Boehmer
中科院分区：
文献类型：
--
作者：
P. H. Krammer;B. Elliott;H. von Boehmer
一部分体内活化为H-2决定簇（ATC）的T细胞在细胞表面表达Fc受体（FcR）。这些FcR可以被抗体包被的红细胞（EA roximol）检测到。通过在单位重力下的速度沉降分离，可以获得高度富集形式（纯度大于99%）的非玫瑰花结和EA玫瑰花结ATC。单独测试，ATC的两个级分显示针对特定靶细胞的杀伤细胞活性。可能的解释为什么只有一个群体的T杀伤细胞表达FcR进行了讨论。
A fraction of T cells activated to H‐2 determinants in vivo (ATC) express Fc receptors (FcR) on the cell surface. Those FcR can be detected by antibody coated red blood cells (EA rosettes). Nonrosetting and EA rosetting ATC could be obtained in highly enriched form (more than 99 % pure) by separation by velocity sedimentation at unit gravity. Separately tested, both fractions of ATC showed killer cell activity against specific target cells. Possible explanations why only one population of T killer cells expressed FcR are discussed.