Inhibition of PDZ domain-mediated interactions.
Inhibition of PDZ domain-mediated interactions.
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DOI：
10.1016/j.ddtec.2012.10.003
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发表时间：
2013-12-01
期刊：
影响因子：
--
通讯作者：
Sainlos, Matthieu
中科院分区：
文献类型：
--
作者：
Grillo-Bosch, Dolors;Choquet, Daniel;Sainlos, Matthieu
调节蛋白质-蛋白质相互作用是研究生物学机制和开发新的治疗方法的一个有前途的策略。在许多类型的相互作用中，PDZ结构域介导的相互作用（PDMI）在过去十年中已经成为药物发现领域中有吸引力的靶点。事实上，这些小结构域参与许多信号传导途径的调节，并具有有利于竞争配体设计的结构特性。在这里，我们描述了最近开发的方法来抑制这类蛋白质-蛋白质相互作用。
Modulating protein-protein interactions constitutes a promising strategy both for the investigation of biological mechanisms and for developing new therapeutic approaches. Among the many types of inter-actions, PDZ domain-mediated interactions (PDMIs) have emerged over the last decade as attractive targets in the drug discovery field. Indeed, these small domains are involved in the regulation of many signaling pathways and possess structural properties which are favorable for the design of competing ligands. Herein, we describe the recent approaches developed to inhibit this class of protein-protein interactions.