Hippocampal volume reduction correlates with apathy in traumatic brain injury, but not schizophrenia.
Hippocampal volume reduction correlates with apathy in traumatic brain injury, but not schizophrenia.
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海马体积减少与创伤性脑损伤的冷漠相关，但与精神分裂症无关。
DOI：
10.1176/appi.neuropsych.12040093
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Cascella,NicolaG
中科院分区：
文献类型：
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作者：
Takayanagi,Yoichiro;Gerner,Gwendoly;Takayanagi,Mizuho;Rao,Vani;Vannorsdall,TracyD;Sawa,Akira;Schretlen,DavidJ;Cascella,NicolaG
尽管神经学基础尚不清楚，但冷漠通常伴随着创伤性脑损伤（TBI）和缺陷综合征精神分裂症（DSZ）。作者利用 3D 磁共振成像 (MRI) 检查了成年 TBI 幸存者、DSZ 患者和健康对照受试者之间皮质厚度和皮质下/小脑区域体积的差异，并将成像结果与冷漠临床评级和选定的认知测试分数相关联。影像学结果揭示了 TBI 幸存者的特定区域体积缩小以及 DSZ 患者的皮质变薄区域。不同患者组的冷漠症状的严重程度相似；然而，冷漠的严重程度仅与 TBI 幸存者的影像学检查结果相关。
Apathy commonly accompanies both traumatic brain injury (TBI) and deficit syndrome schizophrenia (DSZ), despite unclear neurological bases. The authors examined differences in cortical thickness and subcortical/cerebellar regional volumes between adult TBI survivors, patients with DSZ, and healthy-control subjects by use of 3-D magnetic resonance imaging (MRI), and correlated imaging findings with clinical ratings of apathy and selected cognitive test scores. Imaging findings revealed specific areas of volume reduction in TBI survivors and areas of cortical thinning among patients with DSZ. The severity of apathy symptoms was similar across patient groups; however, severity of apathy was only correlated with imaging findings in TBI survivors.