Migraine in the Young Brain: Adolescents vs. Young Adults
Migraine in the Young Brain: Adolescents vs. Young Adults
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DOI：
10.3389/fnhum.2019.00087
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发表时间：
2019-03-22
影响因子：
2.9
通讯作者：
Borsook, David
中科院分区：
文献类型：
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作者：
Colon, Elisabeth;Ludwick, Allison;Borsook, David
偏头痛是一种在青春期末和成年早期达到高峰的疾病。本研究的目的是评估偏头痛患者与年龄性别匹配的健康对照组在两个发育阶段（青春期与青年期）静息状态功能连接（rs-FC）的与年龄相关的大脑变化。在每个发育组、年龄和性别匹配的健康对照以及发育组之间评估该疾病的影响（偏头痛相关的年龄影响）。全球范围内的组内比较表明，青少年中的 rs-FC 异常比年轻人更普遍，而且年轻人中与感觉网络相关的 rs-FC 异常更常见。两组的直接比较显示出一些显着的变化：（1）青少年默认模式网络的连接性变化比年轻人更多； (2) 与年轻人相比，青少年小脑网络中的 rs-FC 更强； (3) 年轻人的执行和感觉运动网络中的 rs-FC 更强。两组中疾病的持续时间和频率与基线内在连接性存在不同的相关性。功能磁共振成像静息状态网络表明，在大脑发育的关键时间点，大脑功能发生显着变化，并且可能导致对该疾病的潜在不同治疗反应。
Migraine is a disease that peaks in late adolescence and early adulthood. The aim of this study was to evaluate age-related brain changes in resting state functional connectivity (rs-FC) in migraineurs vs. age-sex matched healthy controls at two developmental stages: adolescence vs. young adulthood. The effect of the disease was assessed within each developmental group and age- and sex-matched healthy controls and between developmental groups (migraine-related age effects). Globally the within group comparisons indicated more widespread abnormal rs-FC in the adolescents than in the young adults and more abnormal rs-FC associated with sensory networks in the young adults. Direct comparison of the two groups showed a number of significant changes: (1) more connectivity changes in the default mode network in the adolescents than in the young adults; (2) stronger rs-FC in the cerebellum network in the adolescents in comparison to young adults; and (3) stronger rs-FC in the executive and sensorimotor network in the young adults. The duration and frequency of the disease were differently associated with baseline intrinsic connectivity in the two groups. fMRI resting state networks demonstrate significant changes in brain function at critical time point of brain development and that potentially different treatment responsivity for the disease may result.