Evaluation of the inhibitory activities of the extracts of Indonesian traditional medicinal plants against Plasmodium falciparum and Babesia gibsoni
Evaluation of the inhibitory activities of the extracts of Indonesian traditional medicinal plants against Plasmodium falciparum and Babesia gibsoni
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DOI：
10.1292/jvms.67.829
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发表时间：
2005-08-01
影响因子：
1.2
通讯作者：
Yoshihara, T
中科院分区：
文献类型：
--
作者：
Murnigsih, T;Subeki;Yoshihara, T
从印尼爪哇岛22种传统上用于治疗疟疾的植物中提取了24种水提取物，并对其进行了抗疟和抗巴贝虫活性的筛选。其中8种提取物具有较强的抗疟活性，抑制率为89.6%~ 100%; 15种提取物具有较强的抗疟活性，抑制率为84.2%~ 98.1%。结果表明，白千层塔、Baeckea frutensens、鸦胆子、姜黄、马钱子和大叶桃花心木的提取物具有较强的抗疟和杀虫活性。抗疟活性与抗巴贝斯虫活性一致，但匡威则不一致。
Twenty-four kinds of water extracts derived from 22 plants that are traditionally used for the treatment of malaria on Java Island, Indonesia, were screened for their antibabesial and antimalarial activities. Among the extracts, 8 extracts displayed strong antimalarial activity, with an inhibition range from 89.6 to 100%, and 15 showed strong antibabesial activity, with an inhibition range from 84.2 to 98.1%. The extracts of Achillea millefolium, Baeckea frutenscens, Brucea javanica, Curcuma xanthorrhiza, Strychnos lucida and Swietenia macrophylla showed both strong antibabesial and antimalarial activities. The antimalarial activities paralleled the antibabesial activities, but the converse was not true.