LYVE-1, the lymphatic system and tumor lymphangiogenesis
LYVE-1, the lymphatic system and tumor lymphangiogenesis
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DOI：
10.1016/s1471-4906(01)01936-6
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发表时间：
2001-06-01
影响因子：
16.8
通讯作者：
Banerji, S
中科院分区：
文献类型：
--
作者：
Jackson, DG;Prevo, R;Banerji, S
以前对透明质酸（HA）的研究主要集中在这种丰富的组织糖胺聚糖通过与炎性白细胞和肿瘤细胞上的跨膜受体CD 44相互作用促进细胞迁移的作用。最近发现的一种新的HA受体LYVE-1（淋巴管内皮HA受体）主要在淋巴管中表达，突出了HA生物学的另一个方面：它通过淋巴系统的连续转运及其通过CD 44（+）白细胞和肿瘤细胞在淋巴结归巢中的潜在参与。LYVE-1在淋巴管中的功能作用及其作为肿瘤淋巴管生成的标志物的应用是研究的重要领域。
Previous research into hyaluronan (HA) has focused on the role of this abundant tissue glycosaminoglycan in promoting cell migration through interactions with its transmembrane receptor CD44 on inflammatory leukocytes and tumor cells. The recent discovery of a new HA receptor, LYVE-1 (lymphatic vessel endothelial HA receptor), expressed predominantly in lymphatic vessels, highlights another aspect of HA biology: its continuous transit through the lymphatic system and its potential involvement in lymph node homing by CD44(+) leukocytes and tumor cells. The functional role of LYVE-1 in lymphatic vessels and its application as a marker to study tumor lymphangiogenesis are important areas of investigation.