The dynamics of memory: Context-dependent updating
The dynamics of memory: Context-dependent updating
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DOI：
10.1101/lm.1022308
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发表时间：
2008-08-01
影响因子：
2
通讯作者：
Nadel, Lynn
中科院分区：
文献类型：
--
作者：
Hupbach, Almut;Hardt, Oliver;Nadel, Lynn
理解记忆变化的动力学是认知神经科学目前面临的挑战之一。最近关于记忆再巩固的动物研究表明，记忆可以在获得后很长时间内被改变。当重新激活时，记忆可以被修改，需要一个重新稳定（重新巩固）的过程。最近，我们将这一发现扩展到人类的情景记忆，表明记忆的重新激活介导了新信息与现有记忆的结合。在这里，我们表明，空间环境中起着独特的作用，这种类型的记忆更新：在相同的空间背景下，在原有的和新的学习是必要的和足够的新信息纳入现有的情景记忆。当受试者回到原始的学习环境时，记忆会自动重新激活，在那里可以通过合并新内容进行更新。然而，当在一个新的背景下，现有的记忆不会发生更新，而是创建一个新的情景记忆。
Understanding the dynamics of memory change is one of the current challenges facing cognitive neuroscience. Recent animal work on memory reconsolidation shows that memories can be altered long after acquisition. When reactivated, memories can be modified and require a restabilization ( reconsolidation) process. We recently extended this finding to human episodic memory by showing that memory reactivation mediates the incorporation of new information into existing memory. Here we show that the spatial context plays a unique role for this type of memory updating: Being in the same spatial context during original and new learning is both necessary and sufficient for the incorporation of new information into existing episodic memories. Memories are automatically reactivated when subjects return to an original learning context, where updating by incorporating new contents can occur. However, when in a novel context, updating of existing memories does not occur, and a new episodic memory is created instead.