Systems approaches for the study of metabolic cycles in yeast
Systems approaches for the study of metabolic cycles in yeast
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DOI：
10.1016/j.gde.2010.09.008
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发表时间：
2010-12-01
影响因子：
4
通讯作者：
Tu, Benjamin P.
中科院分区：
文献类型：
--
作者：
Laxman, Sunil;Tu, Benjamin P.
四十多年前，就有报道称在酵母细胞的新陈代谢中出现了首次振荡。从那时起，在多种连续培养环境下生长的酵母中观察到了多种形式的振荡行为。经历这种振荡的细胞具有显著的同步性，这使它们成为使用基于系统的方法进行研究的理想对象。在此，我们简要总结了以往使用系统方法对这种振荡进行表征的工作，并将长周期的酵母代谢周期作为一个出色的模型系统，以前所未有的分辨率解读基本细胞和代谢过程的时间组织。
Over four decades ago, the first oscillations in metabolism in yeast cells were reported. Since then, multiple forms of oscillatory behavior have been observed in yeast grown under a variety of continuous culturing environments. The remarkable synchrony of cells undergoing such oscillations has made them ideal subjects for investigation using systems-based approaches. Herein, we briefly summarize previous work on the characterization of such oscillations using systems approaches, and present the long-period, Yeast Metabolic Cycle as an excellent model system for deciphering the temporal organization of fundamental cellular and metabolic processes at unprecedented resolution.