The comparative efficacy of 0.12% chlorhexidine and amoxicillin to reduce the incidence and magnitude of bacteremia during third molar extractions: a prospective, blind, randomized clinical trial
The comparative efficacy of 0.12% chlorhexidine and amoxicillin to reduce the incidence and magnitude of bacteremia during third molar extractions: a prospective, blind, randomized clinical trial
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DOI：
10.1016/j.oooo.2012.11.019
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发表时间：
2013-06-01
影响因子：
2.9
通讯作者：
Vandewalle, Kraig S.
中科院分区：
文献类型：
--
作者：
DuVall, Nicholas B.;Fisher, Tommy D.;Vandewalle, Kraig S.
Objective.本研究的目的是直接比较0.12%洗必泰术前冲洗与AHA和ADA/AAOS推荐的第三磨牙拔除期间2 g阿莫西林抗生素预防的菌血症发生率和程度。本研究是一项随机、设盲、安慰剂对照的前瞻性临床试验，受试者被分配到安慰剂组、冲洗组或抗生素组。分别通过卡方检验和Kruskal-Wallis/Friedman检验分析菌血症的发生率和严重程度。三组间菌血症的发生率和严重程度无统计学显著差异。然而，安慰剂组明显导致菌血症的最大范围和最高平均幅度，其次是冲洗，然后是抗生素组。这项新研究的结果可以合理地得出结论，与无抗菌干预相比，口腔冲洗或全身抗生素抗菌干预不会在统计学上降低菌血症的发生率和程度。
Objective. The purpose of this study was to directly compare the incidence and magnitude of bacteremia of a 0.12% chlorhexidine pre-procedure rinse to the AHA and the ADA/AAOS recommended 2 g amoxicillin antibiotic prophylaxis during third molar extractions.Study Design. This study was a randomized, blind, placebo-controlled prospective clinical trial involving subjects assigned to a placebo, rinse, or antibiotic group. The incidence and magnitude of bacteremia were analyzed via chi(2) and Kruskal-Wallis/Friedman tests, respectively.Results. There was no statistically significant difference in the incidence and magnitude of bacteremia between the three groups. However, the placebo group apparently resulted in the largest range and highest mean magnitude of bacteremia, followed by the rinse then the antibiotic group.Conclusions. The results of this novel study may reasonably conclude an oral rinse or systemic antibiotic antimicrobial intervention does not statistically reduce the incidence and magnitude of bacteremia compared to no antimicrobial intervention.