Adolescent vulnerabilities to chronic alcohol or nicotine exposure: findings from rodent models.
Adolescent vulnerabilities to chronic alcohol or nicotine exposure: findings from rodent models.
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DOI：
10.1097/01.alc.0000179220.79356.e5
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发表时间：
2005-09-01
期刊：
影响因子：
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通讯作者：
Spear, Linda P
中科院分区：
文献类型：
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作者：
Barron, Susan;White, Aaron;Spear, Linda P
本文介绍了一个题为“青春期是特殊的吗？可能与年龄有关的长期酒精或尼古丁暴露的脆弱性，”由苏珊巴伦和琳达斯皮尔组织，并在2004年研究学会酒精中毒会议在温哥华，不列颠哥伦比亚省举行。这次研讨会，胎儿酒精综合征研究小组和神经行为畸形学会共同主办，重点是我们目前的知识，关于酒精和/或尼古丁暴露在青春期的长期后果，重点是从啮齿动物模型的数据。来自这两个协会的支持代表了这些研究小组的理解，即青春期代表了慢性药物暴露影响的独特发展阶段，也标志着许多危险行为，包括饮酒和吸烟通常开始的年龄。发言者包括：（1）Aaron白色，他介绍了青少年接触乙醇对成年后对乙醇挑战的运动或认知反应影响的数据;（2）Richard Bell，他介绍的数据表明，遗传差异可能在青少年对乙醇的脆弱性中发挥作用;（3）克雷格·斯拉韦茨基，他提供了长期接触酒精或尼古丁对神经生理学和行为终点的影响的数据;和（4）艾德·莱文（Ed Levin），他提供了有关青少年尼古丁暴露的急性和长期后果的数据。最后，琳达·斯皮尔就尚未解决的问题和今后的方向提出了一些要点和建议。
This article presents an overview of the proceedings from a symposium entitled "Is adolescence special? Possible age-related vulnerabilities to chronic alcohol or nicotine exposure," organized by Susan Barron and Linda Spear and held at the 2004 Research Society on Alcoholism Meeting in Vancouver, British Columbia. This symposium, co-sponsored by the Fetal Alcohol Syndrome Study Group and the Neurobehavioral Teratology Society, focused on our current knowledge regarding the long-term consequences of ethanol and/or nicotine exposure during adolescence with the emphasis on data from rodent models. The support from these two societies represents the understanding by these research groups that adolescence represents a unique developmental stage for the effects of chronic drug exposure and also marks an age in which many risky behaviors including alcohol consumption and smoking typically begin. The speakers included (1) Aaron White, who presented data on the effects of adolescent ethanol exposure on subsequent motor or cognitive response to an ethanol challenge in adulthood; (2) Richard Bell, who presented data suggesting that genetic differences could play a role in adolescent vulnerability to ethanol; (3) Craig Slawecki, who presented data looking at the effects of chronic exposure to alcohol or nicotine on neurophysiologic and behavioral end points; and (4) Ed Levin, who presented data on acute and long-term consequences of adolescent nicotine exposure. Finally, Linda Spear provided some summary points and recommendations regarding unresolved issues and future directions.