Irritant-Induced Airway Disorders
Irritant-Induced Airway Disorders
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DOI：
10.1016/j.iac.2011.07.002
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发表时间：
2011-11-01
影响因子：
2.6
通讯作者：
Bernstein, I. Leonard
中科院分区：
文献类型：
--
作者：
Brooks, Stuart M.;Bernstein, I. Leonard
每年有数以千计的人遭遇意外的高刺激性暴露，但大多数人康复了，很少有人死亡。刺激物的功能与过敏原不同，因为它们的作用是非特异性的，而且是通过非免疫机制进行的。对于一些人来说，单一大规模暴露在刺激物、气体、蒸汽或烟雾中的后果是持续性的呼吸道高反应性和哮喘的临床症状，称为反应性呼吸道功能障碍综合征(RADS)。反复接触刺激物可能会导致慢性咳嗽和持续的呼吸道高反应性。反复接触刺激物导致哮喘的病例可能是遗传和/或宿主因素的结果。
Thousands of persons experience accidental high-level irritant exposures each year but most recover and few die. Irritants function differently than allergens because their actions proceed nonspecifically and by nonimmunologic mechanisms. For some individuals, the consequence of a single massive exposure to an irritant, gas, vapor or fume is persistent airway hyperresponsiveness and the clinical picture of asthma, referred to as reactive airways dysfunction syndrome (RADS). Repeated irritant exposures may lead to chronic cough and continual airway hyperresponsiveness. Cases of asthma attributed to repeated irritant-exposures may be the result of genetic and/or host factors.