Dynamically configurable Biomolecular nanoarrays
Dynamically configurable Biomolecular nanoarrays
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DOI：
10.1021/nl071643g
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发表时间：
2007-10-01
期刊：
影响因子：
10.8
通讯作者：
Chen, Yong
中科院分区：
文献类型：
--
作者：
Huang, Suxian;Schopf, Eric;Chen, Yong
不同的DNA和蛋白质生物分子的纳米阵列的制造通过电化学控制它们的组装/释放从芯片上的Au纳米电极。组装在阵列中的每个纳米电极上的生物分子的表面密度、比率和活性可以通过调节施加在纳米电极上的电化学电势来定量地和暂时地配置。动态可配置的生物分子纳米阵列可以在用于生物和医学应用的电子电路的控制下潜在地激活与微生物系统的组合相互作用。
Nanoarrays of distinct DNA and protein biomolecules were fabricated by electrochemically controlling their assembly/release from Au nanoelectrodes on a chip. The surface density, ratio, and activity of the biomolecules assembled on each nanoelectrode in the array can be configured quantitatively and temporally by adjusting the electrochemical potential applied on the nanoelectrode. The dynamically configurable biomolecular nanoarray can potentially activate combinatorial interactions with microbiosystems under the control of an electronic circuit for biological and medical applications.