Synergistic antibacterial effect of graphene-coated titanium loaded with levofloxacin
Synergistic antibacterial effect of graphene-coated titanium loaded with levofloxacin
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石墨烯涂层钛负载左氧氟沙星的协同抗菌作用
DOI：
10.1016/j.colsurfb.2021.112090
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Jiayu Lu
中科院分区：
文献类型：
--
作者：
Jiayue Sun;Xuling Liu;Chengqi Lyu;Yinghan Hu;Derong Zou;Yu-Shi He;Jiayu Lu
在本研究中，将石墨烯涂层引入到改性的钛表面，以防止口腔种植体中的细菌感染。我们通过SLA和硅烷化处理对钛表面进行了改性，然后在表面涂覆了石墨烯。用XPS和扫描电子显微镜对其结构和表面性能进行了表征。石墨烯涂层钛片与细菌孵育，通过吸附和释放左氧氟沙星来测试其抗菌性能。我们进一步将负载左氧氟沙星的石墨烯涂层钛片植入兔体内，测试其体内抗菌性能。石墨烯涂层通过膜应力和活性氧(ROS)的产生表现出固有的抗菌性能。当负载左氧氟沙星时，石墨烯涂层显示出协同抗菌效果，并有效地防止了植入后的细菌感染。石墨烯涂层有望改善口腔种植体表面的抗菌功能，防止细菌感染。
In this study, graphene coating was introduced to the modified titanium surface to prevent bacterial infection in oral implants. We modified the titanium surface through SLA and silanization treatment and then coated the surface with graphene. The structure and surface properties were characterized by XPS and SEM. Graphene-coated titanium sheet was incubated with bacteria to test the antibacterial property, which was enhanced by adsorption and release of levofloxacin. We further implanted the graphene-coated titanium sheet loaded with levofloxacin into rabbits to test the antibacterial propertiesin vivo. The graphene coating exhibited inherent antibacterial properties through membrane stress and the generation of reactive oxygen species (ROS). When loaded with levofloxacin, the graphene coating exhibited a synergistic antibacterial effect and effectively prevented bacterial infections following the implantation. The graphene coating is promising to improve the antibacterial functions of oral implant surfaces to prevent bacterial infection.