Usage of Human Mesenchymal Stem Cells in Cell-based Therapy: Advantages and Disadvantages.
Usage of Human Mesenchymal Stem Cells in Cell-based Therapy: Advantages and Disadvantages.
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DOI：
10.12717/dr.2017.21.1.001
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Park JS
中科院分区：
文献类型：
--
作者：
Kim HJ;Park JS
人类间充质干细胞（hMSC）在细胞疗法中的应用引起了再生医学领域的广泛兴趣，并在许多疑难杂症中得到了应用。与其他类型的干细胞相比，hMSC 显示出多种优越的治疗用途特性。讨论了不同细胞类型的优缺点，重点关注 hMSC 的特性。 hMSC 可以很容易地增殖并产生可以替代受影响的目标组织的分化细胞。为了最大限度地发挥 hMSC 的治疗效果，大量的这些细胞是必不可少的，需要大量的离体细胞扩增。然而，hMSC 在体外培养条件下的寿命有限。从临床应用的角度来看，hMSCs的衰老是一把双刃剑。尽管它们有限的细胞增殖能力可以保护它们在移植后免受恶性转化，但衰老可以改变各种细胞功能，包括增殖、分化和迁移，这对于它们的治疗效果至关重要。讨论了许多克服间充质干细胞有限寿命的试验。
The use of human mesenchymal stem cells (hMSCs) in cell-based therapy has attracted extensive interest in the field of regenerative medicine, and it shows applications to numerous incurable diseases. hMSCs show several superior properties for therapeutic use compared to other types of stem cells. Different cell types are discussed in terms of their advantages and disadvantages, with focus on the characteristics of hMSCs. hMSCs can proliferate readily and produce differentiated cells that can substitute for the targeted affected tissue. To maximize the therapeutic effects of hMSCs, a substantial number of these cells are essential, requiring extensive ex vivo cell expansion. However, hMSCs have a limited lifespan in an in vitro culture condition. The senescence of hMSCs is a double-edged sword from the viewpoint of clinical applications. Although their limited cell proliferation potency protects them from malignant transformation after transplantation, senescence can alter various cell functions including proliferation, differentiation, and migration, that are essential for their therapeutic efficacy. Numerous trials to overcome the limited lifespan of mesenchymal stem cells are discussed.