Long noncoding RNA plays a key role in metastasis and prognosis of hepatocellular carcinoma.
Long noncoding RNA plays a key role in metastasis and prognosis of hepatocellular carcinoma.
复制标题
DOI：
10.1155/2014/780521
复制
发表时间：
2014
影响因子：
--
通讯作者：
Zhao H
中科院分区：
文献类型：
--
作者：
Li G;Zhang H;Wan X;Yang X;Zhu C;Wang A;He L;Miao R;Chen S;Zhao H
长链非编码RNA（longnoncodingRNA，lncRNA）是近年来研究的热点。然而，只有少数lncRNA被彻底表征。它们参与基本的细胞过程，包括表观遗传学中的基因表达调控以及肿瘤发生。本文就lncRNA在肝癌中的作用作一系统、全面的综述。本文综述了lncRNA在肝癌发生、预后和转移中的重要作用，阐明了一些特异性lncRNA如MALAT1和HOTAIR在肝癌病理生理中的作用及其作为治疗靶点的潜力。
Long noncoding RNAs (lncRNAs) have been attracting immense research interests. However, only a handful of lncRNAs had been thoroughly characterized. They were involved in fundamental cellular processes including regulation of gene expression at epigenetics as well as tumorogenesis. In this paper, we give a systematic and comprehensive review of existing literature about lncRNA involvement in hepatocellular carcinoma. This review exhibited that lncRNAs played important roles in tumorigenesis and subsequent prognosis and metastasis of hepatocellular carcinoma and elucidated the role of some specific lncRNAs such as MALAT1 and HOTAIR in the pathophysiology of hepatocellular carcinoma and their potential of being therapeutic targets.
登录
查看更多内容
影响因子：
8
作者：
Braconi, C.;Kogure, T.;Valeri, N.;Huang, N.;Nuovo, G.;Costinean, S.;Negrini, M.;Miotto, E.;Croce, C. M.;Patel, T.
通讯作者：
Patel, T.
影响因子：
11.2
作者：
Aguilo F;Zhou MM;Walsh MJ
通讯作者：
Walsh MJ
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
--
作者：
Huang F;Tang L;Fang ZF;Hu XQ;Pan JY;Zhou SH
通讯作者：
Zhou SH
影响因子：
3.4
作者：
Ge, Xiaosong;Chen, Yuanbin;Jia, Weihua
通讯作者：
Jia, Weihua