Adolescent C57BL/6J Mice Show Elevated Alcohol Intake, but Reduced Taste Aversion, as Compared to Adult Mice: A Potential Behavioral Mechanism for Binge Drinking
Adolescent C57BL/6J Mice Show Elevated Alcohol Intake, but Reduced Taste Aversion, as Compared to Adult Mice: A Potential Behavioral Mechanism for Binge Drinking
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DOI：
10.1111/j.1530-0277.2011.01528.x
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发表时间：
2011-10-01
影响因子：
3.2
通讯作者：
Hodge, Clyde W.
中科院分区：
文献类型：
--
作者：
Holstein, Sarah E.;Spanos, Marina;Hodge, Clyde W.
背景：青春期酗酒是一个严重的健康问题，可能会增加未来酒精使用障碍的风险。虽然有几种不同的程序来模拟临床前酗酒，但有限获取程序提供了实现高自愿酒精摄入量和与酒精相关的血液酒精浓度（BAC）的优势。因此，在目前的研究中，发展差异暴饮暴食一样饮酒使用有限的自行车程序进行了检查。此外，由于饮酒与酒精的厌恶属性的敏感性呈负相关，我们研究了酒精诱导的条件性味觉厌恶（CTA）的敏感性的发育差异：在青少年（4周）和成年（10周）雄性C57 BL/6 J小鼠2至4小时/天，16天的饮酒量进行了调查。对酒精诱导的CTA的敏感性的发育差异进行了研究，在青少年和成年小鼠，与盐水或酒精（3或4克/公斤）反复配对的摄入量的一种新的tastant（NaCl）。结果：青少年小鼠表现出显着增加酒精摄入量相比，成年人，与青少年实现更高的BAC和增加酒精消费量在连续周期的狂欢程序。相反，与成年小鼠相比，青春期小鼠对酒精厌恶性的敏感性表现出剂量依赖性降低，青春期小鼠未能发展到3 g/kg酒精的CTA。最后，灭绝的酒精CTA观察到以下条件与较高剂量的酒精在青少年，与成人，mice.Conclusions：这些结果表明，青少年小鼠消耗更多的酒精，每公斤体重，比成年人在一个狂欢样的模型饮酒，并表现出迟钝的敏感性酒精的条件厌恶的影响。总的来说，这支持了一个行为框架，通过这个框架，在青春期发生了酗酒现象，部分原因是对酒精厌恶性的敏感性降低。
Background: Binge alcohol drinking during adolescence is a serious health problem that may increase future risk of an alcohol use disorder. Although there are several different procedures by which to preclinically model binge-like alcohol intake, limited-access procedures offer the advantage of achieving high voluntary alcohol intake and pharmacologically relevant blood alcohol concentrations (BACs). Therefore, in the current study, developmental differences in binge-like alcohol drinking using a limited-access cycling procedure were examined. In addition, as alcohol drinking has been negatively correlated with sensitivity to the aversive properties of alcohol, we examined developmental differences in sensitivity to an alcohol-induced conditioned taste aversion (CTA).Methods: Binge-like alcohol consumption was investigated in adolescent (4 weeks) and adult (10 weeks) male C57BL/6J mice for 2 to 4 h/d for 16 days. Developmental differences in sensitivity to an alcohol-induced CTA were examined in adolescent and adult mice, with saline or alcohol (3 or 4 g/kg) repeatedly paired with the intake of a novel tastant (NaCl).Results: Adolescent mice showed a significant increase in alcohol intake as compared to adults, with adolescents achieving higher BACs and increasing alcohol consumption over successive cycles of the binge procedure. Conversely, adolescent mice exhibited a dose-dependent reduction in sensitivity to the aversive properties of alcohol, as compared to adult mice, with adolescent mice failing to develop a CTA to 3 g/kg alcohol. Finally, extinction of an alcohol CTA was observed following conditioning with a higher dose of alcohol in adolescent, versus adult, mice.Conclusions: These results indicate that adolescent mice consume more alcohol, per kilogram body weight, than adults in a binge-like model of alcohol drinking and demonstrate a blunted sensitivity to the conditioned aversive effects of alcohol. Overall, this supports a behavioral framework by which heightened binge alcohol intake during adolescence occurs, in part, via a reduced sensitivity to the aversive properties of alcohol.