Generalized atherosclerosis, cognitive decline, and depressive symptoms in old age
Generalized atherosclerosis, cognitive decline, and depressive symptoms in old age
复制标题
全身动脉粥样硬化、认知能力下降和老年抑郁症状
DOI：
10.1212/01.wnl.0000167544.54228.95
复制
发表时间：
2005
期刊：
影响因子：
9.9
通讯作者：
J. Gussekloo
中科院分区：
文献类型：
--
作者：
D. Vinkers;M. Stek;R. V. D. Mast;A. Craen;S. Cessie;J. Jolles;R. Westendorp;J. Gussekloo
背景：动脉粥样硬化可能与老年认知功能减退和抑郁有关。方法：莱顿85-Plus研究是一项基于人群的前瞻性研究，研究对象为从85岁起的599名受试者。一般的动脉粥样硬化负荷由基线时心血管病变的数量来评定，由治疗医生的病史和EKG来评估。心血管病理包括心肌梗死、心绞痛或心肌缺血、间歇性跛行和动脉手术。从85岁到90岁，每年评估总体认知功能(简易智力状态检查)、注意力(Stroop测试)、加工速度(字母数字编码测试)、立即回忆(单词学习测试-立即回忆)、延迟回忆(单词学习测试-延迟回忆)和抑郁症状(15个条目的老年抑郁量表)。通过调整性别和教育水平的线性混合模型，分析了广义动脉粥样硬化分级和中风与认知功能和抑郁症状之间的前瞻性关联。结果：随访期间，患者认知功能明显下降，抑郁症状明显增加。在基线时，中风病史与整体认知功能较低、处理速度较慢、即时和延迟回忆记忆受损以及更多抑郁症状相关。此外，较高的综合动脉粥样硬化分级与整体认知功能受损、注意力较低以及基线时处理速度较慢相关。在随访期间，较高的全身性动脉粥样硬化评分与即时回忆记忆和延迟回忆记忆的加速下降有关。相反，无论是在横断面分析还是在前瞻性分析中，普遍的动脉粥样硬化分级和抑郁症状之间都没有关系。结论：在一般人群中，全身性动脉粥样硬化会导致老年认知功能减退，但不会导致抑郁症。
Background: Atherosclerosis may be linked to cognitive decline and depression in old age. Methods: The Leiden 85-Plus Study is a prospective population-based study of 599 subjects from age 85 onward. The generalized atherosclerotic burden was rated by the number of cardiovascular pathologies at baseline, as assessed by history taking from treating physicians and EKG. Cardiovascular pathologies included myocardial infarction, angina pectoris or myocardial ischemia, claudicatio intermittens, and arterial surgery. Global cognitive function (Mini-Mental State Examination), attention (Stroop Test), processing speed (Letter Digit Coding Test), immediate recall memory (Word Learning Test-Immediate Recall), delayed recall memory (Word Learning Test-Delayed Recall), and depressive symptoms (15-item Geriatric Depression Scale) were assessed each year from ages 85 through 90. The prospective associations between both the generalized atherosclerosis rating and stroke with cognitive function and depressive symptoms were analyzed by linear mixed models adjusted for sex and level of education. Results: During follow-up, there was a significant cognitive decline and a significant increase of depressive symptoms. At baseline, a history of stroke was correlated with lower global cognitive function, slower processing speed, impaired immediate and delayed recall memory, and more depressive symptoms. In addition, a higher generalized atherosclerosis rating was correlated with impaired global cognitive function, lower attention, and a slower processing speed at baseline. During follow-up, a higher generalized atherosclerosis rating was associated with an accelerated decline of immediate recall memory and delayed recall memory. In contrast, there was no relation between the generalized atherosclerosis rating and depressive symptoms, either in the cross-sectional analysis or in the prospective analysis. Conclusion: In the population at large, generalized atherosclerosis contributes to cognitive decline in old age but not to depression.
影响因子：
--
作者：
Gueorguieva, R;Krystal, JH
通讯作者：
Krystal, JH
DOI：
10.1001/jama.1997.03540340047031
发表时间：
1997-03-12
影响因子：
120.7
作者：
Snowdon, DA;Greiner, LH;Markesbery, WR
通讯作者：
Markesbery, WR
“血管抑制”假说。
影响因子：
--
作者：
Alexopoulos,GS;Meyers,BS;Young,RC;Campbell,S;Silbersweig,D;Charlson,M
通讯作者：
Charlson,M