Respiratory outcomes in high-risk children 7 to 10 years after prophylaxis with respiratory syncytial virus immune globulin
Respiratory outcomes in high-risk children 7 to 10 years after prophylaxis with respiratory syncytial virus immune globulin
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DOI：
10.1016/s0002-9343(02)01095-1
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发表时间：
2002-06-01
影响因子：
5.9
通讯作者：
Simoes, EAF
中科院分区：
文献类型：
--
作者：
Wenzel, SE;Gibbs, RL;Simoes, EAF
目的：呼吸道合胞病毒感染与哮喘的发生有关。我们评估了呼吸道合胞病毒免疫球蛋白（一种有效预防儿童这些感染的预防剂）对慢性气道疾病高危儿童呼吸和过敏结局的长期影响。13名呼吸道疾病高危儿童（平均[+/-SD]年龄，8.6 +/- 1.1岁）在接受呼吸道合胞病毒免疫球蛋白预防治疗7 - 10年后，通过肺功能和过敏皮肤试验进行评估。为了进行比较，还对26名高风险对照儿童（平均年龄8.5 ± 0.9岁）进行了评估。健康结果数据收集所有科目。结果：儿童的年龄和胎龄相匹配。下呼吸道感染中呼吸道合胞病毒的发生率较低（P
PURPOSE: Respiratory syncytial virus infections have been implicated in the development of asthma. We evaluated the long-term effects of respiratory syncytial virus immune globulin, an effective prophylactic agent for the prevention of these infections in children, on respiratory and allergic outcomes in children at high risk of chronic airway disease.SUBJECTS AND METHODS. Thirteen children at high risk of respiratory disease (mean [+/-SD] age, 8.6 +/- 1.1 years) were evaluated using pulmonary function and allergy skin testing 7 to 10 years after they had received prophylaxis with respiratory syncytial virus immune globulin. For comparison, 26 high-risk control children (mean age, 8.5 +/- 0.9 years) were also evaluated. Health outcomes data were collected from all subjects.RESULTS: The children were matched for age and gestational age. There were more boys, and a lesser frequency of a lower respiratory tract infection with respiratory syncytial virus (P