Obesity leads to higher risk of sperm DNA damage in infertile patients
Obesity leads to higher risk of sperm DNA damage in infertile patients
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DOI：
10.1038/aja.2013.65
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发表时间：
2013-09-01
影响因子：
2.9
通讯作者：
Levy, Rachel
中科院分区：
文献类型：
--
作者：
Dupont, Charlotte;Faure, Celine;Levy, Rachel
在过去的几年里，人们对男性营养对生育的影响越来越感兴趣。不育症与男性超重或肥胖有关，在体重指数(BMI)较高的情况下，传统的精液参数值似乎会发生变化。一些评估BMI对精子DNA完整性的影响的研究已经发表，但它们并没有导致强烈的共识。我们的目标是通过一项为期3年的多中心研究，进一步探索精子DNA完整性与BMI之间的关系。研究对象包括330名不育症夫妇的男性伴侣。采用末端尿苷缺口末端标记法，我们观察到肥胖男性精子DNA损伤率增加(优势比(95%可信区间)：2.5(1.2-5.1))。
There has been a growing interest over the past few years in the impact of male nutrition on fertility. Infertility has been linked to male overweight or obesity, and conventional semen parameter values seem to be altered in case of high body mass index (BMI). A few studies assessing the impact of BMI on sperm DNA integrity have been published, but they did not lead to a strong consensus. Our objective was to explore further the relationship between sperm DNA integrity and BMI, through a 3-year multicentre study. Three hundred and thirty male partners in subfertile couples were included. Using the terminal uridine nick-end labelling (TUNEL) assay, we observed an increased rate of sperm DNA damage in obese men (odds ratio (95% confidence interval): 2.5 (1.2-5.1)).