Perspective on the Effect of Membrane Mimetics on Dynamic Properties of Integral Membrane Proteins
Perspective on the Effect of Membrane Mimetics on Dynamic Properties of Integral Membrane Proteins
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DOI：
10.1021/acs.jpcb.2c07324
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发表时间：
2023-04-20
影响因子：
3.3
通讯作者：
Lorigan，Gary A.
中科院分区：
文献类型：
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作者：
Sahu，Indra D.;Lorigan，Gary A.
整合膜蛋白通过跨越脂质双层的宽度嵌入细胞膜中。它们在生物体生存的重要生物功能中发挥着至关重要的作用。它们的功能包括跨细胞膜运输离子和分子以及启动信号通路。膜整合蛋白的动力学行为对其功能至关重要。由于细胞膜中膜蛋白的复杂行为，使用生物物理方法研究其结构动力学具有挑战性。在这里，我们简要地讨论了挑战和生物物理方法的技术和方法学方面的最新进展，用于收集完整的膜蛋白的动态特性，以回答与这些蛋白质相关的相关生物学问题。
Integral membrane proteins are embedded into cell membranes by spanning the width of the lipid bilayer. They play an essential role in important biological functions for the survival of living organisms. Their functions include the transportation of ions and molecules across the cell membrane and initiating signaling pathways. The dynamic behavior of integral membrane proteins is very important for their function. Due to the complex behavior of integral membrane proteins in the cell membrane, studying their structural dynamics using biophysical approaches is challenging. Here, we concisely discuss challenges and recent advances in technical and methodological aspects of biophysical approaches for gleaning dynamic properties of integral membrane proteins to answer pertinent biological questions associated with these proteins.