Quantitative CT Correlates with Local Inflammation in Lung of Patients with Subtypes of Chronic Lung Allograft Dysfunction.
Quantitative CT Correlates with Local Inflammation in Lung of Patients with Subtypes of Chronic Lung Allograft Dysfunction.
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DOI：
10.3390/cells11040699
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发表时间：
2022-02-16
期刊：
影响因子：
6
通讯作者：
Galbán CJ
中科院分区：
文献类型：
--
作者：
Ram S;Verleden SE;Bell AJ;Hoff BA;Labaki WW;Murray S;Vanaudenaerde BM;Vos R;Verleden GM;Kazerooni EA;Galbán S;Hatt CR;Han MK;Lama VN;Galbán CJ
同种异体肺移植物的慢性排斥反应有两种主要亚型，闭塞性细支气管炎综合征（BOS）和限制性同种异体肺移植物综合征（RAS），其在放射学上表现为小气道疾病的空气潴留或持续性胸膜实质混浊。参数反应图（PRM），计算机断层扫描（CT）的方法，已被证明是一个客观的读出BOS和RAS，并承担预后的重要性，但尚未与生物措施。使用拓扑技术，我们评估了肺移植受者因终末期BOS（N = 6）或RAS（N = 6）而接受再次移植的PRM衍生肺异常分类的分布和排列。从每个PRM分类确定拓扑度量，并与从肺核心样品的microCT和组织病理学确定的结构和生物标志物进行比较。作为BOS读数的PRM定义的功能性小气道疾病（fSAD）的全肺测量值在BOS患者中显著高于RAS患者（p = 0.01）。在核心水平，发现PRM定义的实质疾病（RAS的潜在读数）与中性粒细胞和胶原蛋白I水平相关（p < 0.05）。我们证明了结构和生物标志物的关系，以CT为基础的分布和排列的PRM衍生的读数BOS和RAS。
Chronic rejection of lung allografts has two major subtypes, bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS), which present radiologically either as air trapping with small airways disease or with persistent pleuroparenchymal opacities. Parametric response mapping (PRM), a computed tomography (CT) methodology, has been demonstrated as an objective readout of BOS and RAS and bears prognostic importance, but has yet to be correlated to biological measures. Using a topological technique, we evaluate the distribution and arrangement of PRM-derived classifications of pulmonary abnormalities from lung transplant recipients undergoing redo-transplantation for end-stage BOS (N = 6) or RAS (N = 6). Topological metrics were determined from each PRM classification and compared to structural and biological markers determined from microCT and histopathology of lung core samples. Whole-lung measurements of PRM-defined functional small airways disease (fSAD), which serves as a readout of BOS, were significantly elevated in BOS versus RAS patients (p = 0.01). At the core-level, PRM-defined parenchymal disease, a potential readout of RAS, was found to correlate to neutrophil and collagen I levels (p < 0.05). We demonstrate the relationship of structural and biological markers to the CT-based distribution and arrangement of PRM-derived readouts of BOS and RAS.
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影响因子：
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Belloli, Elizabeth A.;Degtiar, Irina;Lama, Vibha N.
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Lama, Vibha N.
DOI：
10.1164/rccm.202012-4528oc
发表时间：
2021-10-15
影响因子：
24.7
作者：
Belloli, Elizabeth A.;Gu, Tian;Lama, Vibha N.
通讯作者：
Lama, Vibha N.