RENAL DYSFUNCTION IN BRAZILIAN LEAD WORKERS
RENAL DYSFUNCTION IN BRAZILIAN LEAD WORKERS
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DOI：
10.1159/000167519
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发表时间：
1987-11-01
影响因子：
4.2
通讯作者：
ROCHA, H
中科院分区：
文献类型：
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作者：
DEALMEIDA, ARP;CARVALHO, FM;ROCHA, H
在这项研究中，位于巴西东北部的一个初级铅冶炼厂的52名工人的肾功能进行了比较，一个造纸厂的44名其他类似的工人的参考组。肾功能不全，定义为血清肌酐水平≥ 1.5毫克/分升，被发现在17个（32.7%）的工人在铅冶炼厂，接触组，但只有1个（2.3%）的个人从参考组。接触组工人的平均血清尿酸水平也明显较高。暴露组工人的肾功能不全与冶炼厂的就业时间和年龄有统计学相关性，但与血中铅和锌原卟啉水平和尿中δ-氨基乙酰丙酸水平无关。两组的动脉高血压发生率相似。然而，在铅作业工人中，动脉高血压与肾功能不全的相关性更强。
In this study, renal function of 52 workers of a primary lead smelter located in Northeast Brazil was compared to a reference group of 44 otherwise similar workers of a paper mill. Renal dysfunction, defined by a serum creatinine level ≥ 1.5 mg/dl, was found in 17 (32.7%) workers at the lead smelter, the exposed group, but in only 1 (2.3%) individual from the reference group. Workers from the exposed group also showed significantly higher mean serum uric acid levels. Renal dysfunction of workers from the exposed group was statistically associated with duration of the employment at the smelter and with age, but not with the levels of lead and zinc protoporphyrin in blood and δ-aminolevulinic acid in urine. The two groups presented similar rates of arterial hypertension. However, arterial hypertension was much more strongly associated with renal dysfunction in the lead workers.