The CASE adherence index: A novel method for measuring adherence to antiretroviral therapy
The CASE adherence index: A novel method for measuring adherence to antiretroviral therapy
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DOI：
10.1080/09540120500465160
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发表时间：
2006-10-01
影响因子：
1.7
通讯作者：
Finkelstein, R.
中科院分区：
文献类型：
--
作者：
Mannheimer, S. B.;Mukherjee, R.;Finkelstein, R.
依从性支持评估中心 (CASE) 依从性指数是一种自我报告的抗逆转录病毒治疗 (ART) 依从性的简单综合衡量标准，在对全美 12 个依从性计划进行纵向、前瞻性跨地点评估时，将参与者与标准的三天自我报告依从性衡量标准进行了比较。 CASE 依从性指数由为跨中心研究开发的三个独特的依从性问题以及为期三天的依从性自我报告组成，在一年内每三个月通过访谈进行管理。将三个跨站点依从性问题（单独和组合）的数据与三天自我报告数据以及横断面分析中的 HIV RNA 和 CD4 结果进行比较。 CASE 依从性指数与三天自我报告依从性数据密切相关 (p < 0.001)，并且与 HIV 结果密切相关，包括 HIV RNA 水平下降 1 个对数（最大 OR = 2.34；p < 0.05）、HIV RNA < 400 拷贝/ml（最大 OR = 2.33；p < 0.05），并且在以下情况下表现与三天自我报告一样好：预测 CD4 计数状态。 CASE 指数得分 > 10 的参与者在 12 个月内 CD4 计数平均增加了 98 个细胞，而得分为 41 的参与者则增加了 41 个细胞
The Center for Adherence Support Evaluation ( CASE) Adherence Index, a simple composite measure of self-reported antiretroviral therapy (ART) adherence, was compared to a standard three-day self-reported adherence measure among participants in a longitudinal, prospective cross-site evaluation of 12 adherence programs throughout the United States. The CASE Adherence Index, consisting of three unique adherence questions developed for the cross-site study, along with a three-day adherence self-report were administered by interviews every three months over a one-year period. Data from the three cross-site adherence questions (individually and in combination) were compared to three-day self-report data and HIV RNA and CD4 outcomes in cross-sectional analyses. The CASE Adherence Index correlated strongly with the three-day self-reported adherence data (p < 0.001) and was more strongly associated with HIV outcomes, including a 1-log decline in HIV RNA level (maximum OR = 2.34; p < 0.05), HIV RNA < 400 copies/ml (maximum OR = 2.33; p < 0.05) and performed as well as the three-day self-report when predicting CD4 count status. Participants with a CASE Index score > 10 achieved a 98 cell mean increase in CD4 count over 12 months, compared to a 41 cell increase for those with scores