Preprogrammed Long-Term Systemic Pulsatile Delivery of Parathyroid Hormone to Strengthen Bone.
Preprogrammed Long-Term Systemic Pulsatile Delivery of Parathyroid Hormone to Strengthen Bone.
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DOI：
10.1002/adhm.201600901
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发表时间：
2017-02
影响因子：
10
通讯作者：
Ma PX
中科院分区：
文献类型：
--
作者：
Dang M;Koh AJ;Danciu T;McCauley LK;Ma PX
甲状旁腺激素（PTH）是唯一的FDA批准的合成代谢剂用于治疗骨质疏松症。PTH的合成代谢作用取决于PTH给药的方式。脉冲给药促进骨形成，然而持续的PTH暴露导致骨吸收。此外，当剂量和持续时间适合治疗窗时，PTH的治疗效果最佳。目前的PTH治疗需要每天注射，这既不方便也不是患者的有利选择。在这里，开发了一种能够长期脉冲输送PTH的可植入和可生物降解的装置，作为患者友好的替代方案。在这项工作中开发的先进材料和制造技术使我们能够预先编程的脉动输送装置，以系统地提供21个每日脉冲的PTH，在体内建立骨。此外，该器械在体内是可生物降解和可吸收的，因此不需要牵开手术。因此，这种可植入和可生物降解的脉动装置有望促进骨生长并治疗各种骨丢失状况，而无需每日注射或二次手术的负担。一种可植入的脉冲式PTH输送装置被开发为当前每日注射治疗的患者友好的替代方案。使用表面腐蚀聚酸酐和新的逐层技术来构建装置，该装置被预编程为每天输送PTH脉冲21天。脉冲式PTH释放装置显着增加骨系统在体内。
Parathyroid hormone (PTH) is the only FDA approved anabolic agent for the treatment of osteoporosis. The anabolic action of PTH depends on the mode of PTH adminstration. Pulsatile administration promotes bone formation, however continuous PTH exposure results in bone resorption. In addition, the therapeutic effect of PTH is optimal when the dose and duration fit the therapeutic window. Current PTH treatment requires daily injection, which is neither a convenient nor a favorable choice of patients. Here, an implantable and biodegradable device capable of long-term pulsatile delivery of PTH is developed as a patient-friendly alternative. The advanced materials and fabrication techniques developed in this work enable us to preprogram the pulsatile delivery device to systemically deliver 21 daily pulses of PTH that builds bone in vivo. In addition, the device is biodegradable and absorbable in vivo so that no retraction procedure is needed. Therefore, this implantable and biodegradable pulsatile device holds promise to promote bone growth and treat various conditions of bone loss without the burden of daily injections or secondary surgeries. An implantable pulsatile PTH delivery device is developed as a patient-friendly alternative to the current daily injection treatment. Surface erosion polyanhydride and new layer-by-layer technique are used to construct the device that is preprogrammed to delivery daily PTH pulse for 21 days. The pulsatile PTH release from the device significantly increased bone systemically in vivo.