The proline form of p53 codon 72 polymorphism is associated with endometriosis
The proline form of p53 codon 72 polymorphism is associated with endometriosis
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DOI：
10.1016/s0015-0282(01)02938-7
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发表时间：
2002-01-01
影响因子：
6.7
通讯作者：
Lin, CC
中科院分区：
文献类型：
--
作者：
Chang, CC;Hsieh, YY;Lin, CC
目的：探讨子宫内膜异位症与p53基因多态性的关系。设计：前瞻性研究。地点：某医学中心的妇科和遗传学部。患者：有或无子宫内膜异位症的女性。干预：女性分为中度或重度子宫内膜异位症（118例）和无子宫内膜异位症（140例）。主要观察指标：聚合酶链反应检测p53密码子72多态性（精氨酸纯合性、杂合性和脯氨酸纯合性）。评估子宫内膜异位症与p53多态性之间的关系。结果：不同p53多态性在各组间的分布有显著差异。子宫内膜异位症组精氨酸纯合子、杂合子和脯氨酸纯合子比例分别为10.2%、66.9%和22.9%，无子宫内膜异位症组精氨酸纯合子比例分别为30.7%、50%和19.3%。结论：子宫内膜异位症与p53多态性有关，p53精氨酸纯合子发生子宫内膜异位症的风险较低。杂合子和脯氨酸纯合子患子宫内膜异位症的风险较高。植物学报（英文版）2002;77:43-5。(C) 2002年，美国生殖医学学会。
Objective: To evaluate the association between endometriosis and the p53 polymorphism.Design: Prospective study.Setting: Department of gynecology and genetics in a medical center.Patient(s): Women with and without endometriosis.Intervention(s): Women were categorized as having moderate or severe endometriosis (n = 118) or no endometriosis (n = 140).Main Outcome Measure(s): Polymerase chain reaction was used to detect p53 codon 72 polymorphisms (arginine homozygosity, heterozygosity, and proline homozygosity). Associations between endometriosis and p53 polymorphisms were evaluated.Result(s): The distributions of different p53 polymorphisms differed significantly between groups. The respective proportions of arginine homozygotes, heterozygotes, and proline homozygotes were 10.2%, 66.9%, and 22.9% in the group with endometriosis and 30.7%, 50%, and 19.3% in the group without endometriosis.Conclusion(s): Endometriosis is associated with p53 polymorphism, p53 arginine homozygotes have lower risk for endometriosis. Heterozygotes and proline homozygotes have higher risk for endometriosis. (Fertil Steril(R) 2002;77:43-5. (C) 2002 by American Society for Reproductive Medicine.).