Pheochromocytomas:: Detection with 18F DOPA whole-body PET -: Initial results
Pheochromocytomas:: Detection with 18F DOPA whole-body PET -: Initial results
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DOI：
10.1148/radiol.2222010622
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发表时间：
2002-02-01
期刊：
影响因子：
19.7
通讯作者：
Neumann, HPH
中科院分区：
文献类型：
--
作者：
Hoegerle, S;Nitzsche, E;Neumann, HPH
目的：评价氟18 （F-18）二羟基苯丙氨酸（DOPA）全身正电子发射断层扫描（PET）作为一种生化成像方法检测嗜铬细胞瘤。材料与方法：对14例疑似嗜铬细胞瘤患者（5例散发性，9例希佩尔-林道病）进行F-18 DOPA PET和磁共振（MR）成像；其中12例患者进行了metaiodo苄基胍（MIBG）显像。个别影像学结果由核医学专家和对其他方法结果不知情的放射科医生一致评估。将功能成像方法的结果与参考标准MR成像结果进行比较。8例患者9例肿瘤可获得组织学证实。结果：17例嗜铬细胞瘤（单发11例，双焦点3例；肾上腺型14例，肾上腺外型3例）经磁共振成像检出。所有17个肿瘤的F-18 DOPA PET和MR成像结果一致。相比之下，在3个小于2 cm的肾上腺肿瘤和1个直径为3.6 cm的肾上腺外肿瘤的4例患者中，MIBG闪烁成像结果为假阴性。在这些数据的基础上，计算了F-18 DOPA PET的灵敏度为100%，MIBG闪烁成像的灵敏度为71%。两种方法的特异性均为100%。结论：F-18 DOPA PET对嗜铬细胞瘤的检测具有较高的敏感性和特异性，有望成为未来的功能成像方法。
PURPOSE: To evaluate fluorine 18 (F-18) dihydroxyphenylalanine (DOPA) whole-body positron emission tomography (PET) as a biochemical imaging approach for detection of pheochromocytomas.MATERIALS AND METHODS: F-18 DOPA PET and magnetic resonance (MR) imaging were performed in 14 consecutive patients suspected of having pheochromocytomas (five sporadic, nine with von Hippel-Lindau disease); metaiodobenzyl-guanidine (MIBG) scintigraphy was performed in 12 of these patients. The individual imaging findings were assessed in consensus by specialists in nuclear medicine and radiologists blinded to the results of the other methods. The findings of the functional imaging methods were compared with those of MR imaging, the reference standard. Histologic verification could be obtained in eight patients with nine tumors.RESULTS: Seventeen pheochromocytomas (11 solitary, three bifocal; 14 adrenal, three extraadrenal) were detected with MR imaging. F-18 DOPA PET and MR imaging had concordant results in all 17 tumors. In contrast, MIBG scintigraphy had false-negative results in four patients with three adrenal tumors smaller than 2 cm and one extraadrenal tumor with a diameter of 3.6 cm. On the basis of these data, sensitivities of 100% for F-18 DOPA PET and of 71% for MIBG scintigraphy were calculated. Specificity was 100% for both procedures.CONCLUSION: F-18 DOPA PET is highly sensitive and specific for detection of pheochromocytomas and has potential as the functional imaging method of the future.