Total pancreatectomy with islet autotransplantation: summary of a National Institute of Diabetes and Digestive and Kidney diseases workshop.
Total pancreatectomy with islet autotransplantation: summary of a National Institute of Diabetes and Digestive and Kidney diseases workshop.
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DOI：
10.1097/mpa.0000000000000236
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发表时间：
2014-11
期刊：
影响因子：
2.9
通讯作者：
Andersen DK
中科院分区：
文献类型：
--
作者：
Bellin MD;Gelrud A;Arreaza-Rubin G;Dunn TB;Humar A;Morgan KA;Naziruddin B;Rastellini C;Rickels MR;Schwarzenberg SJ;Andersen DK
由国家糖尿病、消化和肾脏疾病研究所 (NIDDK) 主办的研讨会重点关注全胰腺切除联合胰岛自体移植 (TPIAT) 治疗慢性胰腺炎 (CP) 的研究差距和机遇。该会议于2014年7月23日举行，分为五个部分：（1）患者选择、适应症和时机； (2) TPIAT的技术方面； (3)提高自体胰岛移植的成功率； (4) 改善全胰腺切除术后的预后； (5) TPIAT 的注册注意事项。审查了当前的知识状况；特别强调了知识差距和研究需求。共同主题包括需要确定哪些患者最能从 TPIAT 中受益以及何时进行干预、目前外科手术的局限性、糖尿病缓解和改善的潜力、更好地缓解疼痛的机会、该人群的胃肠道并发症以及考虑接受 TPIAT 的 CP 儿童的独特特征。人们反复强调需要建立一个多中心患者登记系统，专门解决 CP 和全胰腺切除术结果以及术后糖尿病结果的复杂性。
A workshop sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) focused on research gaps and opportunities in total pancreatectomy with islet autotransplantation (TPIAT) for the management of chronic pancreatitis (CP). The session was held on July 23, 2014 and structured into five sessions: (1) patient selection, indications, and timing; (2) technical aspects of TPIAT; (3) improving success of islet autotransplantation; (4) improving outcomes after total pancreatectomy; and (5) registry considerations for TPIAT. The current state of knowledge was reviewed; knowledge gaps and research needs were specifically highlighted. Common themes included the need to identify which patients best benefit from and when to intervene with TPIAT, current limitations of the surgical procedure, diabetes remission and the potential for improvement, opportunities to better address pain remission, GI complications in this population, and unique features of children with CP considered for TPIAT. The need for a multicenter patient registry that specifically addresses the complexities of CP and total pancreatectomy outcomes as well as post-surgical diabetes outcomes was repeatedly emphasized.