Lymphatic Filariasis in India : Problems, Challenges and New Initiatives.
Lymphatic Filariasis in India : Problems, Challenges and New Initiatives.
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DOI：
10.1016/s0377-1237(06)80109-7
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发表时间：
2006-10-01
期刊：
影响因子：
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通讯作者：
Sashindran, V K
中科院分区：
文献类型：
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作者：
Agrawal, V K;Sashindran, V K
丝虫病是印度的一个主要公共卫生问题，尽管自 1955 年以来就制定了国家丝虫病控制计划，但目前可能有多达 3100 万微丝虫病患者、2300 万有症状丝虫病病例以及约 4.73 亿人存在潜在感染风险。过去 10 年的进步带来了新的丝虫病诊断/治疗工具和控制策略。新的控制策略旨在通过大规模治疗控制传播，并通过个体患者管理控制疾病。作为 1997 年第 50 届世界卫生大会关于全球消除淋巴丝虫病决议的签署国，印度在七个流行州的 13 个地区启动了修订后的丝虫病控制计划，并进行了大规模药物管理。每年单剂量大规模给药与其他技术相结合，已经消除了日本、台湾、韩国和所罗门群岛的淋巴丝虫病，并显着减少了在中国的传播。在印度，要实现阻断传播和消除传播，需要非常高的治疗覆盖率（可能> 85%）。因此，迫切需要适应区域差异的有效药物输送策略。这需要强有力的宣传工具和战略以及监测和评估消除计划影响的程序。
Filariasis is a major public health problem in India and inspite of existence of the National Filaria Control Programme since 1955, currently there may be up to 31 million microfilaraemics, 23 million cases of symptomatic filariasis, and about 473 million individuals potentially at risk of infection. Over the last 10 years advances have led to new diagnostic/ treatment tools and control strategies for filariasis. The new control strategy aims at transmission control through mass treatment and at disease control through individual patient management. As a signatory to 50(th) World Health Assembly resolution on global elimination of lymphatic filariasis in 1997, revised filariasis control program was launched in India in 13 districts in seven endemic states where mass drug administration was undertaken. Single dose mass administration annually in combination with other techniques has already eliminated lymphatic filariasis from Japan, Taiwan, South Korea and Solomon Islands and markedly reduced the transmission in China. Very high treatment coverage (probably > 85%) is required to achieve interruption of transmission and elimination in India. Hence, there is an urgent need for effective drug delivery strategies that are adapted to regional differences. This requires powerful advocacy tools and strategies as well as procedures for monitoring and evaluating the impact of elimination programme.