New class of oxotechnetium (5+) chelate complexes containing a TcON/sub 2/S/sub 2/ core
New class of oxotechnetium (5+) chelate complexes containing a TcON/sub 2/S/sub 2/ core
复制标题
含有 TcON/sub 2/S/sub 2/ 核心的新型氧锝 (5) 螯合物
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
M. Sohn
中科院分区：
文献类型：
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作者：
A. Davison;Alun G. Jones;C. Orvig;M. Sohn
合成了苯甲酰基保护的二巯基二酰胺（PhCOS（CH/sub 2/）/sub n/CONH）/sub 2/X（n = 1，X =（CH/sub 2/）/sub 2/，（CH/sub 2/）/sub 3/，0-C/sub 6/H/sub 4/; n = 2，X =（CH/sub 2/）/sub 2/和（CH/sub 2/）/sub 3/）.由此，通过在碱中连二亚硫酸钠还原TcO/sub 4//sup -/，（TcO（S（CH/sub 2/）/sub n/CONXNCO（CH/sub 2/）/sub n/S））/sup -/（n = 1，X =（CH/sub 2/）/sub 2/，（CH/sub 2/）/sub 3/，和o-C/sub 6/H/sub 4/; n = 2，X =（CH/sub 2/）/sub 2/）。介绍了配合物及其前体的合成和表征，并讨论了放射性药物的适用性。
The benzoyl-protected dimercaptodiamides (PhCOS(CH/sub 2/)/sub n/CONH)/sub 2/X (n = 1, X = (CH/sub 2/)/sub 2/, (CH/sub 2/)/sub 3/, and 0-C/sub 6/H/sub 4/; n = 2, X = (CH/sub 2/)/sub 2/ and (CH/sub 2/)/sub 3/) have been synthesized. From these, via the sodium dithionite reduction of TcO/sub 4//sup -/ in base, the technetium complexes (TcO(S(CH/sub 2/)/sub n/CONXNCO(CH/sub 2/)/sub n/S))/sup -/ (n = 1, X = (CH/sub 2/)/sub 2/, (CH/sub 2/)/sub 3/, and o-C/sub 6/H/sub 4/; n = 2, X = (CH/sub 2/)/sub 2/) have been prepared. The synthesis and characterization of the complexes, and their precursors, are presented, and the radiopharmaceutical applicability is discussed.