Control of vascular smooth muscle and endothelial cell proliferation and its implication in cardiovascular disease.
Control of vascular smooth muscle and endothelial cell proliferation and its implication in cardiovascular disease.
复制标题
DOI：
10.2741/a240
复制
发表时间：
1998-03
期刊：
影响因子：
--
通讯作者：
I. Spyridopoulos;Vicente Andrés
中科院分区：
文献类型：
--
作者：
I. Spyridopoulos;Vicente Andrés
在体内平衡时，动脉壁中的内皮细胞（EC）和血管平滑肌细胞（VSMC）完全分化并显示出非常低的增殖指数。然而，与终末分化的细胞不同，成熟的EC和VSMC保持其去分化和重新进入细胞周期的能力，以响应多种环境刺激。由于EC和VSMC增殖对包括癌症和心血管疾病在内的多种疾病的发病机制的贡献，已经投入了相当大的努力来阐明这些细胞类型中调节细胞周期进程的机制。这些调节网络和它们可能对心血管疾病的影响在这里进行审查。
At homeostasis, endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) in the arterial wall are fully differentiated and display a very low proliferative index. However, unlike terminally differentiated cells, mature ECs and VSMCs maintain their ability to dedifferentiate and reenter the cell cycle in response to several environmental stimuli. Because of the contribution of EC and VSMC proliferation to the pathogenesis of several diseases, including cancer and cardiovascular disease, considerable effort has been devoted to elucidate the mechanisms that regulate cell cycle progression in these cell types. These regulatory networks and the implications they may have for cardiovascular disease are reviewed here.