Head injury, α-synuclein genetic variability and Parkinson's disease.
Head injury, α-synuclein genetic variability and Parkinson's disease.
复制标题
DOI：
10.1111/ene.12585
复制
发表时间：
2015-05
影响因子：
5.1
通讯作者：
Ritz B
中科院分区：
文献类型：
--
作者：
Lee PC;Bordelon Y;Bronstein J;Sinsheimer JS;Farrer M;Ritz B
在一些但并非全部研究中，头部损伤与帕金森病 (PD) 有关。人群之间对帕金森病的遗传和环境易感性的差异可能是一种解释。我们研究头部受伤和 SNCA 基因变异的联合影响。从 2001 年到 2012 年，我们招募了来自加州中部的 561 例特发性 PD 病例和 721 例人群对照。受试者报告一生中头部受伤情况，并评估 SNCA 5' 区域（D4S3481；Rep1）和 3' UTR（rs356165）的遗传变异性。在针对混杂因素进行调整的无条件逻辑回归模型中，我们测试了头部损伤与遗传风险变异之间的相互作用。携带至少一种 D4S3481 或 rs356165 变体 263bp 等位基因的头部损伤个体的 PD 风险比未头部损伤的非携带者高 3-4.5 倍。然而，头部损伤与 SNCA D4S3481 或 rs356165 之间相互作用的测试没有统计学意义。我们的研究发现一些证据表明头部损伤和 D4S3481 或 rs356165 变异共同增加 PD 风险，但几乎没有证据表明存在相互作用。
Head injury has been linked to Parkinson’s disease (PD) in some but not all studies. Differences in the genetic and environmental susceptibility to PD between populations might be one explanation. We investigate the joint effects of head injuries and SNCA genetic variants. From 2001 to 2012, we enrolled 561 incident idiopathic PD cases and 721 population controls from central California. Subjects reported on head injuries throughout life-time and were assessed for genetic variability in the SNCA 5′ region (D4S3481; Rep1) and 3′ UTR (rs356165). In unconditional logistic regression models adjusted for confounders, we tested for interactions between head injuries and genetic risk variants. PD risk in individuals with head injury who are carriers of at least one 263bp allele in D4S3481 or rs356165 variants was 3–4.5 fold higher compared with non-carriers without head injuries. However, tests for interaction between head injury and SNCA D4S3481or rs356165 were not statistically significant. Our study finds some evidence that head injury and D4S3481 or rs356165 variants jointly increase the risk of PD but little evidence of interaction.
登录
查看更多内容
影响因子：
3.7
作者：
Ritz B;Rhodes SL;Bordelon Y;Bronstein J
通讯作者：
Bronstein J
影响因子：
--
作者：
Schmidt, OI;Heyde, CE;Stahel, PF
通讯作者：
Stahel, PF
影响因子：
2.2
作者：
McCarthy, Jeanette J.;Linnertz, Colton;Saucier, Laura;Burke, James R.;Hulette, Christine M.;Welsh-Bohmer, Kathleen A.;Chiba-Falek, Ornit
通讯作者：
Chiba-Falek, Ornit
影响因子：
3.5
作者：
Myhre, R.;Toft, M.;Farrer, M. J.
通讯作者：
Farrer, M. J.
影响因子：
5.3
作者：
Uryu, K;Giasson, BI;Trojanowski, JQ
通讯作者：
Trojanowski, JQ