Cholinergic modulation of respiratory brain-stem neurons and its function in sleep-awake state determination
Cholinergic modulation of respiratory brain-stem neurons and its function in sleep-awake state determination
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DOI：
10.1046/j.1440-1681.2000.03192.x
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发表时间：
2000-01-01
影响因子：
2.9
通讯作者：
Funk, GD
中科院分区：
文献类型：
--
作者：
Bellingham, MC;Funk, GD
1. 行为状态的改变是由脑干/脑桥神经元胆碱能和胺能群放电的相互变化控制的。在快速眼动（REM）睡眠期间，胆碱能神经元最活跃，胺能神经元最不活跃。在快速眼动睡眠期间，呼吸中枢控制发生显著变化；呼吸频率和变异性降低，脑干呼吸神经元放电普遍增强，部分呼吸运动神经元池输出抑制。舌下运动神经元（NM）在快速眼动睡眠期间控制舌运动及其抑制与阻塞性睡眠呼吸暂停有关。HM抑郁的细胞基础已经在体外进行了研究，可能是由于胆碱能受体的激活增强或胺能受体的激活减少。显示呼吸节律发生的体外制剂对研究呼吸状态依赖性变化的神经化学基础具有优势。小鼠节律性脑干切片记录的HM呼吸调节中的胆碱能变化依赖于胆碱能受体的激活位置。
1. Shifts in behavioural state are controlled by reciprocal changes in discharge of cholinergic and aminergic groups of brain-stem/pontine neurons. During rapid eye movement (REM) sleep, cholinergic neurons are most active and aminergic neurons are least active.2. Significant changes occur in the central control of breathing during REM sleep; respiration rate inn-eases in frequency and variability, brain-stem respiratory neuron discharge is generally enhanced and the outputs of some respiratory motor neuron pools are depressed.3. Hypoglossal motor neurons (NM) control tongue movement and their depression during REM sleep has been implicated in obstructive sleep apnoea. The cellular basis of HM depression has been investigated in vitro and may be due to enhanced activation of cholinergic receptors or decreased activation of aminergic receptors.4. In vitro preparations that show respiratory rhythmogenesis possess advantages for the investigation of the neurochemical basis of state-dependent changes in respiration. Cholinergic changes in respiratory modulation of HM recorded in rhythmic brain-stem slices from mice depend on the site of activation of cholinergic receptors.