MECHANISM BY WHICH GLUCOSE STIMULATES THE PASSIVE ABSORPTION OF SMALL SOLUTES BY THE HUMAN JEJUNUM IN-VIVO
MECHANISM BY WHICH GLUCOSE STIMULATES THE PASSIVE ABSORPTION OF SMALL SOLUTES BY THE HUMAN JEJUNUM IN-VIVO
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DOI：
10.1016/0016-5085(94)90163-5
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发表时间：
1994-08-01
期刊：
影响因子：
29.4
通讯作者：
FORDTRAN, JS
中科院分区：
文献类型：
--
作者：
FINE, KD;ANA, CAS;FORDTRAN, JS
背景/目的：葡萄糖的主动吸收刺激小溶质的被动吸收。这种效果的部分原因可能是葡萄糖引起的水分吸收。如果随着水从管腔中移除，管腔溶质浓度增加，则增加的吸水率可以通过溶剂阻力和被动扩散增强被动溶质吸收。本研究的目的是量化葡萄糖增强木糖吸收时这两种力的贡献。方法：在木糖浓度一定的情况下，通过测定低渗性木糖吸收对吸水率的影响，确定溶剂拖动对木糖吸收的影响。通过测定吸水率为0时木糖浓度对木糖吸收的影响，确定扩散对木糖吸收的影响。结果：葡萄糖使木糖吸收增加1.8 mmol·h−1·30 cm−1（从1.4到3.2 mmol·h−1·30 cm−1）。溶剂阻力增加1.03 mmol·h−1·30 cm−1；被动扩散增加0.75 mmol·h−1·30 cm−1。结论：葡萄糖刺激木糖被动吸收时，溶剂阻力增加57%，被动扩散增加42%。由于这两种力的联合作用可占观察到的效应的99%，因此几乎所有的葡萄糖效应-木糖吸收都可以用葡萄糖诱导的吸水来解释。
Background/Aims:Active absorption of glucose stimulates passive absorption of small solutes. Part of this effect may be caused by glucose-induced water absorption. Increased water absorption can enhance passive solute absorption by solvent drag and by passive diffusion if the luminal solute concentration increases as water is removed from the lumen. The purpose of this research was to quantitate the contribution of these two forces when glucose enhances the absorption ofl-xylose.Methods:The effect of solvent drag onl-xylose absorption was determined by measuring the effect of water absorption stimulated by hypotonicity onl-xylose absorption when thel-xylose concentration was constant. The effect of diffusion onl-xylose absorption was determined by measuring the effect ofl-xylose concentration onl-xylose absorption when water absorption was nil.Results:Glucose increasedl-xylose absorption by 1.8 mmol·h−1·30 cm−1(from 1.4 to 3.2 mmol·h−1·30 cm−1). The increase attributable to solvent drag was 1.03 mmol·h−1·30 cm−1; the increase attributable to passive diffusion was 0.75 mmol·h−1·30 cm−1.Conclusions:When glucose stimulates the passive absorption ofl-xylose, 57% of the increase can be attributed to solvent drag and 42% to passive diffusion. Because the combined effect of these two forces can account for 99% of the observed effect, virtually all of the glucose effect onl-xylose absorption can be explained by glucose-induced water absorption.