Erinacine A increases catecholamine and nerve growth factor content in the central nervous system of rats
Erinacine A increases catecholamine and nerve growth factor content in the central nervous system of rats
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DOI：
10.1016/j.nutres.2005.06.001
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发表时间：
2005-06-01
影响因子：
4.5
通讯作者：
Yokogoshi, H
中科院分区：
文献类型：
--
作者：
Shimbo, M;Kawagishi, H;Yokogoshi, H
神经生长因子（NGF）是支持周围交感神经元生长和维持的重要蛋白质。从培养的猴头菌菌丝中分离出一种新的二萜类尿嘧啶，已知对NGF合成有强烈的刺激作用。在体内，鸡碱及其相关化合物对大脑的影响尚不清楚。在本研究中，我们检测了鼠碱A对神经生长因子和儿茶酚胺产生的影响，儿茶酚胺刺激大鼠大脑中神经生长因子的合成。大鼠从出生到断奶前3周插管给药，第4 ~ 5周灌胃给药。用该化合物处理的大鼠在4周龄时蓝斑（LC）的去甲肾上腺素和同型香草酸水平升高，在5周龄时LC和海马的NGF水平升高。证实了尿嘧啶A对大鼠中枢神经系统的作用。(c) 2005爱思唯尔公司版权所有。
Nerve growth factor (NGF) is an essential protein for supporting growth and maintenance of peripheral sympathetic neurons. A novel diterpenoid erinacine, isolated from the cultured mycelia of Hericium erinacium, is known to have a potent stimulating effect on NGF synthesis. The effects of erinacine and related compounds in the brain in vivo are not known. In this study, we examined the effects of erinacine A on the production of NGF and catecholamines which stimulate NGF synthesis in the brain of rats. Rats were treated with erinacine A by intubation for the first 3 weeks from birth to weaning and intragastrically from weeks 4 to 5. Rats treated with this compound had increased levels of both noradrenaline and homovanillic acid in the locus coeruleus (LC) at 4 weeks of age and increased levels of NGF in both LC and hippocampus at 5 weeks of age. The effects of erinacine A were confirmed in the central nervous system in rats. (c) 2005 Elsevier Inc. All rights reserved.