Lifestyle for Brain Health (LIBRA): a new model for dementia prevention
Lifestyle for Brain Health (LIBRA): a new model for dementia prevention
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DOI：
10.1002/gps.4700
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发表时间：
2018-01-01
影响因子：
4
通讯作者：
van Boxtel, Martin P. J.
中科院分区：
文献类型：
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作者：
Schiepers, Olga J. G.;Kohler, Sebastian;van Boxtel, Martin P. J.
目的最近在系统评价中确定并汇编了痴呆症的可改变危险因素。大脑健康生活方式 (LIBRA) 分数反映了某人预防痴呆症的潜力，该分数是在基于人口的大型纵向样本中进行研究的，旨在预测长达 16 年观察期内的认知变化。方法大脑健康生活方式是根据马斯特里赫特老龄化研究中 949 名 50-81 岁参与者的基线计算的。通过使用 Cox 比例风险模型并测试其与认知能力下降的关系，检查了 LIBRA 对痴呆症和认知障碍事件的预测价值。结果有利于大脑健康的生活方式预测了未来患痴呆症的风险以及认知障碍的风险。 LIBRA 评分每增加 1 分，患痴呆症的风险就会增加 19%，认知障碍的风险就会增加 9%。 LIBRA 预测了处理速度的下降速度，但没有预测记忆力或执行功能的下降速度。 结论 通过针对可改变的、生活方式相关的风险因素，大脑健康生活方式 (LIBRA) 可能有助于识别和监测痴呆症预防计划中的风险状态。版权所有 (c) 2017 约翰·威利父子有限公司
ObjectiveModifiable risk factors for dementia were recently identified and compiled in a systematic review. The Lifestyle for Brain Health' (LIBRA) score, reflecting someone's potential for dementia prevention, was studied in a large longitudinal population-based sample with respect to predicting cognitive change over an observation period of up to 16years.MethodsLifestyle for Brain Health was calculated at baseline for 949 participants aged 50-81years from the Maastricht Ageing Study. The predictive value of LIBRA for incident dementia and cognitive impairment was examined by using Cox proportional hazard models and by testing its relation with cognitive decline.ResultsLifestyle for Brain Health predicted future risk of dementia, as well as risk of cognitive impairment. A one-point increase in LIBRA score related to 19% higher risk for dementia and 9% higher risk for cognitive impairment. LIBRA predicted rate of decline in processing speed, but not memory or executive functioning.ConclusionsLifestyle for Brain Health (LIBRA) may help in identifying and monitoring risk status in dementia-prevention programmes, by targeting modifiable, lifestyle-related risk factors. Copyright (c) 2017 John Wiley & Sons, Ltd.