Self-assembly of surfactant-like peptides
Self-assembly of surfactant-like peptides
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DOI：
10.1021/la7011183
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发表时间：
2007-12-04
期刊：
影响因子：
3.9
通讯作者：
Butler, Michael F.
中科院分区：
文献类型：
--
作者：
Adams, Dave J.;Holtzmann, Kathrin;Butler, Michael F.
受最近描述表面活性剂样肽的工作的启发，我们对具有V6D2的基本组成的肽进行了系统的研究，改变绝对序列以确定表面活性剂样结构的重要性。这里检查的所有肽在水中形成自组装结构。然而，与其他报道相比，我们发现了令人惊讶的结构多样性，包括纤维，带和扭曲的带，但没有之前描述的囊泡和纳米管。进一步的研究表明，肽纯度在自组装的结果中起着重要作用。不同批次的行为非常不同，这可能与这些批次的成分有关。这项工作表明，有必要不仅合理的设计，但也易于合成的积木自组装结构。
Inspired by recent work describing surfactant-like peptides, we have carried out a systematic study on peptides with the underlying composition Of V6D2, altering the absolute sequence to determine the importance of the surfactant-like structure. All of the peptides examined here formed self-assembled structures in water. However, in contrast to other reports, we have found a surprising diversity of structures including fibers, tapes, and twisted ribbons but an absence of the vesicles and nanotubes described previously. Further investigations demonstrated that peptide purity plays a significant role in the outcome of the self-assembly. Different batches behave very differently, which can be linked to the compositions of these batches. This work shows that there is a need for not only rational design but also ease of synthesis of the building blocks for self-assembled structures.