Low dose nesiritide and the preservation of renal function in patients with renal dysfunction undergoing cardiopulmonary-bypass surgery - A double-blind placebo-controlled pilot study
Low dose nesiritide and the preservation of renal function in patients with renal dysfunction undergoing cardiopulmonary-bypass surgery - A double-blind placebo-controlled pilot study
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DOI：
10.1161/circulationaha.106.697250
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发表时间：
2007-09-11
期刊：
影响因子：
37.8
通讯作者：
Burnett, John C., Jr.
中科院分区：
文献类型：
--
作者：
Chen, Horng H.;Sundt, Thoralf M.;Burnett, John C., Jr.
Background - Renal insufficiency is associated with increased morbidity and mortality after cardiopulmonary bypass cardiac surgery. B-type natriuretic peptide is a cardiac hormone that enhances glomerular filtration rate and inhibits aldosterone. Cystatin has been shown to be a better endogenous marker of renal function than creatinine.Methods and Results - We performed a double-blinded placebo-controlled proof of concept pilot study in patients (n = 40) with renal insufficiency preoperatively (defined as an estimated creatinine clearance of
