The effects of ototoxicity on the auditory brain stem response and the scalp‐recorded cochlear microphonic in guinea pigs
The effects of ototoxicity on the auditory brain stem response and the scalp‐recorded cochlear microphonic in guinea pigs
复制标题
耳毒性对豚鼠听觉脑干反应和头皮记录耳蜗微音的影响
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
D. Jewett
中科院分区：
文献类型：
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作者：
V. L. Schwent;J. S. Williston;D. Jewett
“宝贝,宝贝,宝贝,用诱发反应技术客观测定听力损伤可能在耳毒性反应的早期检测中有价值，特别是在婴儿和其他“困难”的患者群体中。在这项研究中，记录了豚鼠在两种强度和两种重复频率下对“咔哒声”的听觉脑干反应，这些豚鼠被给予两种剂量的卡那霉素或没有药物。头皮记录的耳蜗麦克风的连续音调也被记录下来。三分之一接受卡那霉素治疗的动物出现听力损失。在不同动物之间，这种缺陷的时间过程差别很大。听觉系统的变化在低强度刺激下最容易被检测到，而点击重复频率的变化对结果没有影响。耳蜗麦克风电位与听觉脑干反应相关。
“ldquo;ldquo;ldquo;he objective determination of hearing impairment with evoked response techniques may be of value in the early detection of ototoxic reactions, especially in infants and other “difficult” patient populations. In this study the auditory brain stem response to “clicks” at two intensities and two repetition rates were recorded from guinea pigs that had been given one of two dosage levels of kanamycin or no drug. The scalp‐recorded cochlear microphonic to continuous tones was also recorded. Hearing loss was seen in one‐third of the animals receiving kanamycin. The temporal course of the deficit varied considerably between animals. Auditory system change was most readily detected in response to low‐intensity stimuli, while change in repetition rate of the clicks did not affect the results. The cochlear microphonic potentials correlated with the auditory brain stem response.