Ovulation induction/intrauterine insemination in infertile couples is associated with low-birth-weight infants
Ovulation induction/intrauterine insemination in infertile couples is associated with low-birth-weight infants
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DOI：
10.1067/mob.2003.5
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发表时间：
2003-03-01
影响因子：
9.8
通讯作者：
Fleming, R
中科院分区：
文献类型：
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作者：
Gaudoin, M;Dobbie, R;Fleming, R
目的：这项研究是为了确定通过排卵诱导和宫腔内人工授精（使用伴侣的（OI/IUI）或供体精子（OI/IUID））受孕的单胎妊娠的结局，并与全国队列中自然受孕的单胎妊娠进行比较。在接受OI/IUI（n = 97）或OI/IUD（n = 35）治疗的妊娠晚期女性中开展的回顾性队列研究1993年3月至1997年3月在格拉斯哥皇家医院，并在同一时期分娩的苏格兰国家队列（n = 109，443）中确定。单变量和多变量Logistic回归模型被用来检查结果，并确定与不孕治疗和低出生体重的相关因素。结果：OI/IUI单胎更可能是轻，临床低出生体重，出生更早比自然受孕。调整相关因素后，这些婴儿是4.85倍（95%CI 2.25-10.48），可能是低出生体重。我们不能证明OI/IUI和自然conception.CONCLUSION之间的任何差异：低生育力的母亲通过OI/IUI怀孕的单胎的围产期结局是较差的，比匹配的自然conception. CONCLUSION。我们认为，生育力低下夫妇的内在因素使他们容易生下较小的婴儿，并且“不孕症”应该被添加到与低出生体重相关的公认因素列表中。
OBJECTIVE: The study was undertaken to determine the outcome of singleton pregnancies conceived through ovulation induction and intrauterine insemination using a partner's (OI/IUI) or donor sperm (OI/IUID) by comparison with naturally conceived singletons within a national cohort.STUDY DESIGN: Retrospective cohort study in primigravid women who were treated with OI/IUI (n = 97) or OI/IUID (n = 35) at Glasgow Royal Infirmary between March 1993 and March 1997 and identified within the Scottish national cohort (n = 109,443) delivering during the same period. Univariate and multivariate logistic regression models were used to examine outcomes and to determine the factors associated with infertility treatment and low birth weight.RESULTS: OI/IUI singletons were more likely to be lighter, of clinically low birth weight, and born more prematurely than natural conceptions. After adjustment for associated factors, these infants were 4.85 times (95% CI 2.25-10.48) more, likely to be of low birth weight. We could not demonstrate any differences between OI/IUID and natural conceptions.CONCLUSION: The perinatal outcome of singletons born to subfertile mothers conceived through OI/IUI is poorer than that of matched natural conceptions. We suggest that intrinsic factors in subfertile couples predispose them to having smaller infants and that "infertility" should be added to the list of recognized factors associated with low birth weight.