Bioabsorbable polymer optical waveguides for deep-tissue photomedicine.
Bioabsorbable polymer optical waveguides for deep-tissue photomedicine.
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DOI：
10.1038/ncomms10374
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发表时间：
2016-01-19
影响因子：
16.6
通讯作者：
Yun SH
中科院分区：
文献类型：
--
作者：
Nizamoglu S;Gather MC;Humar M;Choi M;Kim S;Kim KS;Hahn SK;Scarcelli G;Randolph M;Redmond RW;Yun SH
光子学的进步刺激了医学的重大进步，许多技术现在已在常规临床应用。然而，光在组织中的穿透深度有限，严重限制了临床应用。在这里，我们展示了由生物衍生或生物相容性和可生物降解聚合物制成的植入式光传输装置。传统的光纤在使用后必须很快从体内取出，与之相反，可生物降解和生物相容性的波导可以用于长期的光传输，并且不需要被取出，因为它们会逐渐被组织吸收。作为概念的证明，我们展示了光化学组织键合（PTB）的范式转换方法。使用梳状平面波导，我们实现了猪皮肤的全厚度（bbb10毫米）伤口闭合，这代表了传统PTB组织面积的10倍扩展。这一结果为光医学在深部组织中的应用指明了一个新的方向。光疗法在医学中越来越重要，尽管穿透组织并到达目标区域可能很困难。在这里，作者报告了生物可降解波导的使用，能够将光引导到需要的地方，并展示了伤口愈合的潜力。
Advances in photonics have stimulated significant progress in medicine, with many techniques now in routine clinical use. However, the finite depth of light penetration in tissue is a serious constraint to clinical utility. Here we show implantable light-delivery devices made of bio-derived or biocompatible, and biodegradable polymers. In contrast to conventional optical fibres, which must be removed from the body soon after use, the biodegradable and biocompatible waveguides may be used for long-term light delivery and need not be removed as they are gradually resorbed by the tissue. As proof of concept, we demonstrate this paradigm-shifting approach for photochemical tissue bonding (PTB). Using comb-shaped planar waveguides, we achieve a full thickness (>10 mm) wound closure of porcine skin, which represents ∼10-fold extension of the tissue area achieved with conventional PTB. The results point to a new direction in photomedicine for using light in deep tissues. Light-based therapies are of growing importance in medicine, though penetrating tissue and reaching the targeted area can be difficult. Here, the authors report the use of biodegradable waveguides capable of directing light where desired, and demonstrate the potential for wound healing.