Vascular Graft Pressure-Flow Monitoring Using 3D Printed MWCNT-PDMS Strain Sensors.
Vascular Graft Pressure-Flow Monitoring Using 3D Printed MWCNT-PDMS Strain Sensors.
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使用 3D 打印的 MWCNT-PDMS 应变传感器监测血管移植物压力流量。
DOI：
10.1109/embc.2018.8512997
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Zorman,ChristianA
中科院分区：
文献类型：
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作者：
SteveMajerus,JA;Chong,Hao;Ariando,David;Swingle,Connor;Potkay,Joseph;Bogie,Kath;Zorman,ChristianA
动静脉移植物血流的实时监测将提供移植物失效的早期警告，以允许诸如血管成形术或移植物置换的干预，以避免灾难性的失效。我们已经开发出一种新型的柔性脉动传感器（FPS），由一个3D打印的弹性袖带包裹在移植物周围，因此不与血液接触。FPS使用分散在聚二甲基硅氧烷（PDMS）中的多壁碳纳米管（MWCNT）作为压阻传感器层，该压阻传感器层嵌入结构触变性PDMS中。这些材料专门开发用于通过3D生物绘图实现传感器增材制造，并且所得应变传感器比移植物材料更具顺应性并且具有更宽的最大应变范围。在这里，我们分析了血管移植物上的应变转导力学，并描述了MWCNT-PDMS复合材料的忆阻特性，这可以使用AC偏压来减轻。FPS在血管移植物体模上的体外测试显示，对于脉动流（170-650 mL/min）和压力（62-175 mmHg），传感器输出具有稳健的线性。FPS在测量7.7 mmHg和29.3 mL/min的压力和流量时显示RMS误差，平均测量误差为6.5%（压力）和8.0%（流量）。
Real-time monitoring of arteriovenous graft blood flow would provide early warning of graft failure to permit interventions such as angioplasty or graft replacement to avoid catastrophic failure. We have developed a new type of flexible pulsation sensor (FPS) consisting of a 3D printed elastic cuff wrapped around a graft and thus not in contact with blood. The FPS uses multi-walled carbon nanotubes (MWCNTs) dispersed in polydimethylsiloxane (PDMS) as a piezoresistive sensor layer, which is embedded within structural thixotropic PDMS. These materials were specifically developed to enable sensor additive manufacturing via 3D Bio-plotting, and the resulting strain sensor is more compliant and has a wider maximum strain range than graft materials. Here, we analyze the strain transduction mechanics on a vascular graft and describe the memristive properties of MWCNT-PDMS composites, which may be mitigated using AC biasing. In vitro testing of the FPS on a vascular graft phantom showed a robust, linear sensor output to pulsatile flows (170-650 mL/min) and pressures (62-175 mmHg). The FPS showed an RMS error when measuring pressure and flow of 7.7 mmHg and 29.3 mL/min, with a mean measurement error of 6.5% (pressure) and 8.0% (flow).