METHYLPHENIDATE IN AGGRESSIVE-HYPERACTIVE BOYS .1. EFFECTS ON PEER AGGRESSION IN PUBLIC-SCHOOL SETTINGS
METHYLPHENIDATE IN AGGRESSIVE-HYPERACTIVE BOYS .1. EFFECTS ON PEER AGGRESSION IN PUBLIC-SCHOOL SETTINGS
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DOI：
10.1097/00004583-199009000-00006
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发表时间：
1990-09-01
影响因子：
13.3
通讯作者：
PAOLICELLI, L
中科院分区：
文献类型：
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作者：
GADOW, KD;NOLAN, EE;PAOLICELLI, L
哌醋甲酯在多动症儿童中最少被记录的“已知”作用之一是抑制同伴攻击。在这项研究中，11名攻击性多动儿童在双盲条件下接受了低剂量（0.3 mg/kg）和中等剂量（0.6 mg/kg）的哌甲酯和安慰剂各2周。在公立学校的教室座位活动，午餐和休息期间观察儿童。结果表明，哌醋甲酯抑制了课堂上的非身体攻击（p = 0.06），中等剂量的哌醋甲酯降低了操场上的身体攻击（p < 0.01）和言语攻击（p = 0.07）。对适当的社会互动率的影响是可变的。与安慰剂相比，0.6 mg/kg剂量组大多数受试者表现出相同或更高水平的适当社会互动。在课堂上，两种剂量的哌甲酯也导致运动水平降低，任务外行为，不服从和破坏性。教师评级的多动症和行为问题的症状显示药物的影响，而平行的家长工具没有。
One of the least documented ''''known'''' effects of methylphenidate in hyperactive children is the suppression of peer aggression. In this study, 11 aggressive-hyperactive children received a low (0.3 mg/kg) and moderate (0.6 mg/kg) dose of methylphenidate and placebo for 2 weeks each under double-blind conditions. Children were observed in public school settings during classroom seatwork activities, lunch, and recess. Results showed that methylphenidate suppressed nonphysical aggression (p = 0.06) in the classroom, and a moderate dose decreased physical aggression (p < 0.01) and verbal aggression (p = 0.07) on the playground. The effect on the rate of appropriate social interaction was variable. The majority of subjects exhibited either the same or higher levels of appropriate social interaction on the 0.6 mg/kg dose compared with placebo. In the classroom, both doses of methylphenidate also resulted in reduced levels of motor movement, off-task behavior, noncompliance, and disruptiveness. Teacher ratings of hyperactivity and conduct problem symptoms revealed drug effects, whereas parallel parent instruments did not.