The role of breastfeeding in prevention of neonatal infection.
The role of breastfeeding in prevention of neonatal infection.
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DOI：
10.1053/siny.2002.0124
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发表时间：
2002-08-01
期刊：
影响因子：
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通讯作者：
Korotkova, Marina
中科院分区：
文献类型：
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作者：
Hanson, Lars A;Korotkova, Marina
人类新生儿的免疫系统非常有限。它迅速膨胀，特别是由于暴露于肠道微生物菌群。正常情况下，新生儿在分娩时和分娩后会被来自母亲肠道植物群的微生物定殖。母乳中的许多防御因子包括由淋巴细胞产生的大量分泌型伊加抗体，这些淋巴细胞从母亲的肠道迁移到乳腺。因此，SIgA抗体主要针对母亲以前和最近的肠道微生物菌群。因此，母乳喂养调节了新生儿肠粘膜对微生物的早期暴露，并限制了细菌通过肠粘膜的移位。这可能是母乳喂养有效防止新生儿败血症以及其他几种感染的主要原因。牛奶的防御因子已经在粘膜水平上防止了感染。经胎盘获得的母体IgG抗体主要在组织中进行保护，并且这样做的代价是尼古丁诱导的临床症状、组织接合和高能量消耗。
The immune system of the human newborn is of very limited size. It expands rapidly, especially due to the exposure to the gut microflora. Normally the newborn is colonized with microbes from the mother's intestinal flora at and after delivery. The many defence factors of the mother's milk include large amounts of secretory IgA antibodies produced by lymphocytes which have migrated from the mother's gut to the mammary glands. Therefore the SIgA antibodies are mainly directed against the mother's previous and recent gut microflora. Thus breastfeeding modulates the early exposure of the neonate's intestinal mucosa to microbes and limits bacterial translocation through the gut mucosa. This may be a major reason why breastfeeding protects efficiently against neonatal septicaemia, as well as several other infections. The defence factors of the milk prevent infections already at the mucosal level. The transplacentally obtained maternal IgG antibodies protect primarily in tissues and do so at the cost of cytokine-induced clinical symptoms, tissue engagement and high energy consumption.