Alcohol consumption and risk of atrial fibrillation in men and women -: The Copenhagen City Heart Study
Alcohol consumption and risk of atrial fibrillation in men and women -: The Copenhagen City Heart Study
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DOI：
10.1161/circulationaha.105.547844
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发表时间：
2005-09-20
期刊：
影响因子：
37.8
通讯作者：
Gronbæk, M
中科院分区：
文献类型：
--
作者：
Mukamal, KJ;Tolstrup, JS;Gronbæk, M
背景-全方位的酒精消费与事件房颤的风险的关系一直不一致，在以前的，主要是病例对照研究。方法和结果-在一项前瞻性队列研究中，我们研究了自我报告的酒精使用和事件之间的关联房颤16 415名妇女和男子参加了哥本哈根市心脏研究。我们确定使用啤酒，葡萄酒和烈酒分别在多达3个研究访问的结构化问卷。我们通过常规研究ECG和经验证的全国所有住院登记确定了房颤病例。随访期间共发生1071例。在女性和男性中，适度饮酒与房颤风险无关。然而，男性每周饮酒35次或以上的风险比为1.45（95%CI 1.02至2.04）;很少有女性饮酒。大约5%的男性房颤病例可归因于大量饮酒。进一步调整血压、冠心病和充血性心力衰竭的发生率并没有减弱这种相关性（危险比1.63; 95%CI 1.15 - 2.31）。结论-至少在男性中，大量饮酒与房颤的高风险相关。这种关系似乎与大量饮酒对冠心病或血压的不良影响无关。
Background - The relationship of the full range of alcohol consumption with risk of incident atrial fibrillation has been inconsistent in previous, mainly case-control studies.Methods and Results - In a prospective cohort study, we studied the association between self-reported alcohol use and incident atrial fibrillation among 16 415 women and men enrolled in the Copenhagen City Heart Study. We ascertained use of beer, wine, and spirits individually at up to 3 study visits with a structured questionnaire. We identified cases of atrial fibrillation by routine study ECGs and a validated nationwide registry of all hospitalizations. A total of 1071 cases occurred during follow-up. Among both women and men, alcohol consumption throughout the moderate range was not associated with risk of atrial fibrillation. However, consumption of 35 or more drinks per week among men was associated with a hazard ratio of 1.45 (95% CI 1.02 to 2.04); few women consumed this amount of alcohol. Approximately 5% of cases of atrial fibrillation among men were attributable to heavy alcohol use. Further adjustment for blood pressure and incident coronary heart disease and congestive heart failure did not attenuate the association ( hazard ratio 1.63; 95% CI 1.15 to 2.31).Conclusions - Heavy alcohol consumption is associated with a higher risk of atrial fibrillation, at least among men. This relationship does not appear to be related to the adverse effects of heavy drinking on coronary heart disease or blood pressure.