Brain connectivity in West syndrome.
Brain connectivity in West syndrome.
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DOI：
10.1016/j.seizure.2014.03.016
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发表时间：
2014-08
影响因子：
3
通讯作者：
Holmes, Gregory L.
中科院分区：
文献类型：
--
作者：
Burroughs, Scott A.;Morse, Richard P.;Mott, Steven H.;Holmes, Gregory L.
Hypsarrhythmia, the pathognomonic EEG pattern of West syndrome, is typically characterized by a high amplitude, arrhythmic, and asynchronous pattern. While this severely aberrant pattern would suggest severe abnormalities in connectivity, coherence has not yet been systematically assessed in hypsarrhythmia. We evaluated the EEGs of 28 infants, 12 with infantile spasms with hypsarrhythmia and 16 similarly age control infants for coherence and spectral power. Children with infantile spasms and hypsarrhythmia EEGs had marked abnormalities in coherence and spectral power compared to normal children of similar ages. During sleep increases in delta, theta, alpha and beta coherences were seen, particularly at long inter-electrode distances while at short inter-electrode distances coherences were decreased in the theta and beta range, particularly in the frontal region. The enhanced coherences at long inter-electrode distances suggest that during sleep in children with infantile spasms widely spread cortical region do not have functional differentiation whereas in the frontal lobe there is reduced functional connectivity and integration of local cortical regions. Children with continued seizures and developmental delay showed persistent abnormalities in coherence. This study demonstrates that hypsarrhythmic EEGs have marked abnormalities in coherence spectral power and such abnormalities may be related to cognitive impairment.
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DOI：
10.1016/0013-4694(86)90107-0
发表时间：
1986-08-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
THATCHER, RW;KRAUSE, PJ;HRYBYK, M
通讯作者：
HRYBYK, M
影响因子：
3.5
作者：
Lega, Bradley C.;Jacobs, Joshua;Kahana, Michael
通讯作者：
Kahana, Michael
影响因子：
5.3
作者：
Senior, Timothy J.;Huxter, John R.;Csicsvari, Jozsef
通讯作者：
Csicsvari, Jozsef
影响因子：
9.3
作者：
Duffy FH;Als H
通讯作者：
Als H
影响因子：
3
作者：
Srinivasan, Ramesh;Winter, William R.;Nunez, Paul L.
通讯作者：
Nunez, Paul L.