Pattern formation in the Drosophila eye
Pattern formation in the Drosophila eye
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DOI：
10.1016/j.gde.2007.05.001
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发表时间：
2007-08-01
影响因子：
4
通讯作者：
Carthew, Richard W.
中科院分区：
文献类型：
--
作者：
Carthew, Richard W.
昆虫复眼是生物世界中最精确、最有序的图案之一。通过一系列细胞命运的决定和复杂的形态发生运动，它从一个没有图案的简单上皮发展而来。在变态的最初几天，这种相互作用尤其明显。最近的洞察揭示了相邻细胞之间的相互作用是如何推动这一过程的。锥体细胞上的Delta与相邻细胞表面的Notch蛋白相互作用，诱导第一批色素细胞分化。然后，初级色素细胞表达一种名为Hibris的Nephin蛋白，该蛋白与邻近细胞上的另一种Nephin相互作用，最粗糙的。Hibra和Rroughest之间的异嗜性粘连会重塑细胞之间的接触，从而有利于它们与色素细胞的接触。同时，初级色素细胞通过EGF受体向邻近细胞发出信号，要求其存活，而不是经历凋亡。这种分类和剔除过程产生了一个雕刻的图案，每个复眼重复数百次，具有精确的细胞数量和位置。
The insect compound eye is one of the most precise and highly ordered patterns in the living world. It develops from an unpatterned simple epithelium by a series of cell fate decisions and complex morphogenetic movements. In the first days of metamorphosis, this interplay is particularly noticeable. Recent insights have revealed how interactions between neighboring cells drive the process. Interaction between Delta on cone cells and Notch proteins on the surface of their neighbors induces the first pigment cells to differentiate. The primary pigment cells then express a Nephrin protein, Hibris, that interacts with a different Nephrin, Roughest, on their neighbors. Heterophilic adhesion between Hibris and Roughest results in remodeling contacts between cells to favor their contact with the pigment cells. In conjunction, the primary pigment cells signal to their neighbors through the EGF receptor to survive, rather than undergo apoptosis. This sorting and culling process results in a sculpted pattern with a precise number and position of cells that is repeated hundreds of times in each compound eye.