SNOMAD (Standardization and NOrmalization of MicroArray Data): web-accessible gene expression data analysis
SNOMAD (Standardization and NOrmalization of MicroArray Data): web-accessible gene expression data analysis
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DOI：
10.1093/bioinformatics/18.11.1540
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发表时间：
2002-11-01
期刊：
影响因子：
5.8
通讯作者：
Pevsner, J
中科院分区：
文献类型：
--
作者：
Colantuoni, C;Henry, G;Pevsner, J
nomad是一组用于规范化和标准化来自不同生物和技术来源的基因表达数据集的算法集合。除了传统的转换和可视化工具外，nomad还包括两种非线性转换，用于校正在微阵列元件信号强度范围内不均匀分布的偏差和方差：(1)局部均值归一化；(2)局部方差校正（使用局部计算的标准差生成z分数）。
SNOMAD is a collection of algorithms for the normalization and standardization of gene expression datasets derived from diverse biological and technological sources. In addition to conventional transformations and visualization tools, SNOMAD includes two non-linear transformations which correct for bias and variance which are non-uniformly distributed across the range of microarray element signal intensities: (1) Local mean normalization; and (2) Local variance correction (Z-score generation using a locally calculated standard deviation).